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dc.contributor.author
Romero, Stella Maris
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dc.contributor.author
Comerio, Ricardo Mario
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dc.contributor.author
Romero, Andrea Irene
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dc.contributor.author
Giudicessi, Silvana Laura
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dc.contributor.author
Vitale, Roxana Gabriela
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dc.date.available
2022-05-16T16:53:36Z
dc.date.issued
2021-03
dc.identifier.citation
Romero, Stella Maris; Comerio, Ricardo Mario; Romero, Andrea Irene; Giudicessi, Silvana Laura; Vitale, Roxana Gabriela; Evaluation of the activity of crude extracts from semi-arid soil fungi against clinical yeasts and molds; Mushroom Research Foundation; Current Research in Environmental & Applied Mycology; 11; 3-2021; 76-89
dc.identifier.issn
2229-2225
dc.identifier.uri
http://hdl.handle.net/11336/157630
dc.description.abstract
In recent years, the incidence and severity of fungal diseases has increased, particularly in populations with a broad list of immunocompromised conditions. Moreover, the emergence of azole resistance is arising. For these reasons and the small number of available antifungal agents, searching for new and effective compounds with antifungal activity is mandatory. The aim of this study was to evaluate the antifungal activity of crude extracts from semi-arid soil fungi against strains of clinical molds and yeasts. For screening purposes crude extracts of fifteen isolates, corresponding to ten fungal species, were preliminarily explored against Candida albicans ATCC6414 by diffusion methodology. Special focus was placed on Aspergillus tatenoi, Leiothecium ellipsoideum, Subplenodomus violicola and Trichoderma saturnisporum extracts because of their preceding antifungal performance. Crude extracts of these species were once more examined and assayed against 54 yeast and 24 molds including the genera Aspergillus, Candida and Cryptococcus. Antifungal susceptibility testing by microdilution methodology was performed. Activity, as the percentage of clinical strains inhibited by different extract concentrations, ranged from 60.5% to 100% for A. tatenoi, L. ellipsoideum and T. saturnisporum extracts. On the other hand, S. violicola extract was active against all the strains tested with MIC values ≤ 0.25 µg/mL. This study dealt with active crude extracts; particularly, the extract from S. violicola has shown a potent and promising antifungal activity. The composition of the active fractions and the mechanisms of action involved remain to be studied and warrant further investigations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mushroom Research Foundation
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIFUNGAL ACTIVITY
dc.subject
ASPERGILLUS
dc.subject
CANDIDA
dc.subject
CRUDE EXTRACTS
dc.subject
MINIMAL INHIBITORY CONCENTRATION
dc.subject.classification
Micología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Evaluation of the activity of crude extracts from semi-arid soil fungi against clinical yeasts and molds
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-12T06:48:59Z
dc.journal.volume
11
dc.journal.pagination
76-89
dc.journal.pais
China
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dc.journal.ciudad
Beijing
dc.description.fil
Fil: Romero, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Comerio, Ricardo Mario. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina
dc.description.fil
Fil: Romero, Andrea Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Micología y Botánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Micología y Botánica; Argentina
dc.description.fil
Fil: Giudicessi, Silvana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
dc.description.fil
Fil: Vitale, Roxana Gabriela. Universidad de Buenos Aires. Facultad de Medicina. Centro Universitario de Neurología "Dr. José María Ramos Mejía".; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Current Research in Environmental & Applied Mycology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5943/cream/11/1/7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.creamjournal.org/volume-11
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