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dc.contributor.author
Ferraris, Augusto
dc.contributor.author
Szmulewicz, Alejandro G.
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Posadas Martinez, Maria Lourdes
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Serena, Marina Alonso
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Vazquez, Fernando Javier
dc.contributor.author
Angriman, Federico
dc.date.available
2022-04-20T16:23:10Z
dc.date.issued
2019-08
dc.identifier.citation
Ferraris, Augusto; Szmulewicz, Alejandro G.; Posadas Martinez, Maria Lourdes; Serena, Marina Alonso; Vazquez, Fernando Javier; et al.; The Effect of Antipsychotic Treatment on Recurrent Venous Thromboembolic Disease: A Cohort Study; Physicians Postgraduate Press; Journal of Clinical Psychiatry; 80; 5; 8-2019; 1-13
dc.identifier.uri
http://hdl.handle.net/11336/155429
dc.description.abstract
BACKGROUND: Venous thromboembolism (VTE) represents a major cause of morbidity and mortality worldwide. Antipsychotic treatment is associated with an increased risk of thromboembolic disease, an effect that seems to be constant across the spectrum of distinct agents. This study sought to delineate the effect of new antipsychotic use on the risk of recurrent thromboembolic events after a first episode of either deep venous thrombosis or pulmonary embolism. METHODS: This cohort study, conducted between January 2010 and June 2017, was based on a prospectively collected database of adult patients with VTE. The main exposure was the new onset of antipsychotic treatment after having a first episode of venous thromboembolic disease. The primary outcome was defined as recurrent VTE, either deep venous thrombosis or pulmonary embolism, during long-term follow-up. The composite of all-cause mortality and recurrent VTE served as the secondary outcome. An inverse probability weighted multivariable Cox proportional hazards model was fitted to adjust for measured confounding and competing risks. RESULTS: One thousand one hundred three patients were included in the present analysis, of whom 136 were identified as new users of antipsychotic agents. A total of 67% of patients were currently treated with full-dose anticoagulation at baseline. No association was found between the new use of antipsychotic agents and recurrent VTE during follow-up (adjusted hazard ratio (HR) = 1.08; 95% CI, 0.38-3.08). However, the use of these agents was associated with a 63% increased risk of recurrent VTE or all-cause mortality (adjusted HR = 1.63; 95% CI, 1.26-2.10). CONCLUSIONS: The use of antipsychotic agents among patients with a first episode of VTE and full-dose anticoagulation was not associated with an increased risk of recurrent thromboembolic events. However, antipsychotic treatment was associated with a higher risk of both VTE and all-cause mortality. Further studies are warranted to confirm these findings.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Physicians Postgraduate Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TROMBOSIS VENOSA
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Hematología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The Effect of Antipsychotic Treatment on Recurrent Venous Thromboembolic Disease: A Cohort Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-18T13:38:21Z
dc.identifier.eissn
1555-2101
dc.journal.volume
80
dc.journal.number
5
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Memphis
dc.description.fil
Fil: Ferraris, Augusto. Universidad de Buenos Aires; Argentina. Hospital Italiano; Argentina
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Fil: Szmulewicz, Alejandro G.. Universidad de Buenos Aires; Argentina. Harvard University. Harvard School of Public Health; Estados Unidos
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Fil: Posadas Martinez, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
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Fil: Serena, Marina Alonso. Hospital Italiano; Argentina
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Fil: Vazquez, Fernando Javier. Hospital Italiano; Argentina
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Fil: Angriman, Federico. University of Toronto; Canadá. Sunnybrook Health Sciences Centre; Canadá
dc.journal.title
Journal of Clinical Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4088/JCP.18m12656
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.psychiatrist.com/jcp/schizophrenia/psychotic-disorders/antipsychotics-and-recurrent-venous-thromboembolism/
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