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dc.contributor.author
Rial, Marcela Silvina
dc.contributor.author
Seremeta, Katia Pamela
dc.contributor.author
Esteva, Mónica Inés
dc.contributor.author
Bua, Jacqueline Elena
dc.contributor.author
Salomon, Claudio Javier
dc.contributor.author
Fichera, Laura Edith
dc.date.available
2022-03-03T16:29:50Z
dc.date.issued
2020-12
dc.identifier.citation
Rial, Marcela Silvina; Seremeta, Katia Pamela; Esteva, Mónica Inés; Bua, Jacqueline Elena; Salomon, Claudio Javier; et al.; In vitro studies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model; Cambridge University Press; Parasitology; 148; 5; 12-2020; 566-575
dc.identifier.issn
0031-1820
dc.identifier.uri
http://hdl.handle.net/11336/152853
dc.description.abstract
Chagas disease is a serious parasitic infection caused by Trypanosoma cruzi. Unfortunately, the current chaemotherapeutic tools are not enough to combat the infection. The aim of this study was to evaluate the trypanocidal activity of benznidazole-loaded microparticles during acute phase of Chagas infection in an experimental murine model. Microparticles were prepared by spray-drying using copolymers derived from esters of acrylic and methacrylic acids as carriers. Dissolution efficiency of the formulations was up to 3.80-fold greater than that of raw benznidazole. Stability assay showed no significant difference (p>0.05) in loading capacity of microparticles for three years. Cell cultures showed no visible morphological changes or destabilization of the cell membrane nor haemolysis was observed in defibrinated human blood after microparticles treatment. Mice with acute lethal infection survived 100% after 30-days treatment with benznidazole microparticles (50 mg/kg/day). Furthermore, no detectable parasite load measured by quantitative polymerase chain reaction and lower levels of T. cruzi-specific antibodies by enzyme-linked immunosorbent assay were found in those mice. A significant decrease in inflammation of heart tissue after treatment with these microparticles was observed, in comparison with the inflammatory damage observed in both infected mice treated with raw benznidazole and untreated infected mice. Therefore, these polymeric formulations are an attractive approach to treat Chagas disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BENZNIDAZOLE
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CHAGAS DISEASE
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EUDRAGIT
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EXPERIMENTAL INFECTION
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MICROPARTICLES
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SPRAY-DRYING
dc.subject.classification
Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
In vitro studies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-23T13:27:17Z
dc.identifier.eissn
1469-8161
dc.journal.volume
148
dc.journal.number
5
dc.journal.pagination
566-575
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Rial, Marcela Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
dc.description.fil
Fil: Seremeta, Katia Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Basicas y Aplicadas. Laboratorio de Procesos Quimicos.; Argentina
dc.description.fil
Fil: Esteva, Mónica Inés. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
dc.description.fil
Fil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Tecnología Educativa; Argentina
dc.description.fil
Fil: Fichera, Laura Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
dc.journal.title
Parasitology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0031182020002310
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/abs/in-vitro-studies-and-preclinical-evaluation-of-benznidazole-microparticles-in-the-acute-trypanosoma-cruzi-murine-model/255A3CB9771E2349D2430B7683CDF4C4
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