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dc.contributor.author
Gomez Rosso, Leonardo Adrián
dc.contributor.author
Benítez, María Belén
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Fornari, María Cecilia
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Berardi, Vanina
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Lynch, Santiago
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Schreier, Laura Ester
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Wikinski, Regina
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Cuniberti, Luis Alberto
dc.contributor.author
Brites, Fernando Daniel
dc.date.available
2022-02-21T17:22:24Z
dc.date.issued
2008-12
dc.identifier.citation
Gomez Rosso, Leonardo Adrián; Benítez, María Belén; Fornari, María Cecilia; Berardi, Vanina; Lynch, Santiago; et al.; Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome; Elsevier Ireland; Atherosclerosis; 199; 2; 12-2008; 415-423
dc.identifier.issn
0021-9150
dc.identifier.uri
http://hdl.handle.net/11336/152397
dc.description.abstract
Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective of the present study was to determine whether leukocitary and soluble cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Cell adhesion molecules, mainly of leukocitary location, have been not previously evaluated in specifically designed cross-sectional studies involving male patients with metabolic syndrome. Moreover, other circulating markers of different candidate atherogenic risk parameters were also studied and the potential existence of a progressive relation between the number of metabolic syndrome components and the above mentioned biomarkers was analyzed. Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male control subjects were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors. Patients with metabolic syndrome showed (a) hypoadiponectinemia (4551 ± 2302 ng/ml vs. 5865 ± 2548 ng/ml, respectively; p < 0.05), (b) an atherogenic lipid and lipoprotein profile, (c) altered HDL chemical composition accompanied by higher cholesteryl ester-triglyceride interchange carried out by CETP, (d) diminished Lp-PLA2 activity (6.5 ± 1.9 vs. 7.3 ± 2.2, p < 0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and (e) high soluble (VCAM-1: 17 ± 5 vs. 13 ± 4 ng/ml, respectively; p < 0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52 ± 15 vs. 45 ± 12 arbitrary units, respectively; p < 0.0005; and lymphocyte CD49d: 312 ± 56 vs. 284 ± 64 arbitrary units, respectively; p < 0.05). The increment in leukocyte and soluble cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to type 2 diabetes and atherosclerotic cardiovascular disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADHESION MOLECULES
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ADIPONECTIN
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ATHEROSCLEROSIS
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BIOMARKERS
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INFLAMMATION
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METABOLIC SYNDROME
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-03T20:49:04Z
dc.journal.volume
199
dc.journal.number
2
dc.journal.pagination
415-423
dc.journal.pais
Irlanda
dc.description.fil
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Benítez, María Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Fornari, María Cecilia. No especifíca;
dc.description.fil
Fil: Berardi, Vanina. No especifíca;
dc.description.fil
Fil: Lynch, Santiago. Universidad Favaloro; Argentina
dc.description.fil
Fil: Schreier, Laura Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
dc.description.fil
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad Favaloro; Argentina
dc.description.fil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Atherosclerosis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(07)00735-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.atherosclerosis.2007.11.007
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