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dc.contributor.author
Winograd, Milena Raquel
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dc.contributor.author
Viola, Haydee Ana Maria
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dc.date.available
2022-02-17T16:00:32Z
dc.date.issued
2004-12
dc.identifier.citation
Winograd, Milena Raquel; Viola, Haydee Ana Maria; Detection of novelty, but not memory of spatial habituation, is associated with an increase in phophorylated cAMP response element-binding protein levels in the hippocampus; Wiley-liss, div John Wiley & Sons Inc.; Hippocampus; 14; 1; 12-2004; 117-123
dc.identifier.issn
1050-9631
dc.identifier.uri
http://hdl.handle.net/11336/152207
dc.description.abstract
There is a growing body of evidence showing that the formation of associative memories is associated with an increase in phosphorylated cAMP response element-binding protein (pCREB) levels. We recently reported that pCREB level increased in the rat hippocampus after an exploration to a novel environment. In the present work, we studied whether this increment in CREB activation is associated with the formation of memory of habituation to a novel environment or with the detection of novelty. Rats were submitted to consecutive open field sessions at 3 h intervals. Hippocampal pCREB level measurement, performed 1 hour after each training-sessions, revealed that: a) it did not increase when rats explored a familiar environment; b) it did not increase after a re-exposure that improves the memory of habituation; c) it increased after a brief novel exploration unable to form memory of habituation and d) it also increased in amnesic rats for spatial habituation. Taken as a whole, our results suggest that the elevated pCREB level after a single open field exploration is not associated with the memory formation of habituation. It is indeed associated with the detection of a novel environment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MULTIPLE TRIALS
dc.subject
NONASSOCIATIVE LEARNING
dc.subject
OPEN FIELD
dc.subject
PCREB
dc.subject
SPATIAL NOVELTY
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Detection of novelty, but not memory of spatial habituation, is associated with an increase in phophorylated cAMP response element-binding protein levels in the hippocampus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-26T17:15:43Z
dc.journal.volume
14
dc.journal.number
1
dc.journal.pagination
117-123
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Winograd, Milena Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Viola, Haydee Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.journal.title
Hippocampus
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/hipo.10153
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hipo.10153
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