Artículo
Target-based screening of the chagas box: Setting up enzymatic assays to discover specific inhibitors across bioactive compounds
Fecha de publicación:
07/2019
Editorial:
Bentham Science Publishers
Revista:
Current Medicinal Chemistry
ISSN:
0929-8673
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin America with about 6 million people infected and many more being at risk. Only two drugs are available for treatment, Nifurtimox and Benznidazole, but they have a number of side effects and are not effective in all cases. This makes urgently necessary the development of new drugs, more efficient, less toxic and affordable to the poor people, who are most of the infected population. In this review we will summarize the current strategies used for drug discovery considering drug repositioning, phenotyping screenings and target-based approaches. In addition, we will describe in detail the considerations for setting up robust enzymatic assays aimed at identifying and validating small molecule inhibitors in high throughput screenings.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IIBIO)
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Citación
Salas Sarduy, Emir; Niemirowicz, Gabriela Teresa; Cazzulo, Juan Jose; Alvarez, Vanina Eder; Target-based screening of the chagas box: Setting up enzymatic assays to discover specific inhibitors across bioactive compounds; Bentham Science Publishers; Current Medicinal Chemistry; 26; 36; 7-2019; 6672-6686
Compartir
Altmétricas