Artículo
Sexual dimorphism of neuroendocrine-immune interactions
Fecha de publicación:
12/2002
Editorial:
Karger
Revista:
Frontiers in Hormone Research
ISSN:
0301-3073
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.
Palabras clave:
adrenal
,
dimorphism
,
CRH axis
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIB)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Articulos(INIBIOMA)
Articulos de INST. DE INVEST.EN BIODIVERSIDAD Y MEDIOAMBIENTE
Articulos de INST. DE INVEST.EN BIODIVERSIDAD Y MEDIOAMBIENTE
Citación
Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy; Sexual dimorphism of neuroendocrine-immune interactions; Karger; Frontiers in Hormone Research; 29; 12-2002; 91-107
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