Capítulo de Libro

The efficiency of multi-target drugs: A network approach

Título del libro: Approaching complex diseases

Alberca, Lucas NicolásIcon ; Talevi, AlanIcon
Otros responsables: Bizarri, Mariano
Fecha de publicación: 2020
Editorial: Springer
ISSN: 2661-8923
e-ISSN: 2661-8915
ISBN: 978-3-030-32856-6
Idioma: Inglés
Clasificación temática:

Resumen

Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly valuable in the fields of complex disorders and infectious diseases. We discuss the generalities of tailored multi-target drug design, including target combination choice, optimization of potency ratio to the different targets, peculiarities of computer-guided drug discovery and design considerations.
Palabras clave: MULTI-TARGET DRUG , NETWORK PHARMACOLOGY , SYSTEMS BIOLOGY , NETWORKS , COMPLEX DISORDERS , COMPLEX DISEASES , DRUG DISCOVERY
 
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Tamaño: 337.5Kb
Formato: PDF
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Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/146760
URL: https://link.springer.com/book/10.1007/978-3-030-32857-3#about
DOI: http://dx.doi.org/10.1007/978-3-030-32857-3_3
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Citación
Alberca, Lucas Nicolás; Talevi, Alan; The efficiency of multi-target drugs: A network approach; Springer; 2020; 63-75
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