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dc.contributor.author
Srivastava, Alok
dc.contributor.author
Santagostino, Elena
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Dougall, Alison
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Kitchen, Steve
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Sutherland, Megan
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Pipe, Steven W.
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Carcao, Manuel
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Mahlangu, Johnny
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Ragni, Margaret V.
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Windyga, Jerzy
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Llinás, Adolfo
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Goddard, Nicholas J.
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Mohan, Richa
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Poonnoose, Pradeep M.
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Feldman, Brian M.
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Lewis, Sandra Zelman
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van den Berg, H. Marijke
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Pierce, Glenn F.
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de Brasi, Carlos Daniel
dc.date.available
2021-11-09T18:03:07Z
dc.date.issued
2020-08
dc.identifier.citation
Srivastava, Alok; Santagostino, Elena; Dougall, Alison; Kitchen, Steve; Sutherland, Megan; et al.; WFH Guidelines for the Management of Hemophilia; Wiley; Haemophilia The Official Journal Of The World Federation Of Hemophilia; 26; S6; 8-2020; 1-158
dc.identifier.issn
1365-2516
dc.identifier.uri
http://hdl.handle.net/11336/146465
dc.description.abstract
This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 2012, tremendous advances have been made in several aspects of the management of hemophilia. These include genetic assessment as well as therapy with many innovative therapeutic products including extended half-life factor VIII (FVIII) and factor IX (FIX) products, a bi-specific antibody, and hemostasis rebalancing drugs now in clinical development. All of these allow for more effective hemostasis than was possible in the past. Laboratory monitoring of therapies is better defined and prophylaxis is accepted as the only way to change the natural history of bleeding. There are highly effective therapies for patients with inhibitors. Outcome assessment with validated clinimetric instruments is widely advocated and practiced. All these advances are reflected in this third edition of the WFH guidelines, with new chapters devoted to several of these topics along with a new chapter on principles of care that aims to provide a framework for development of a comprehensive healthcare system for hemophilia including advocacy and empowerment for people with hemophilia (PWH). The recommendations in this edition were all developed through a formal evidence-informed and consensus-based methodology involving multidisciplinary healthcare professionals (HCPs) and well-informed PWH. While directed primarily at HCPs, these guidelines should also be very useful for PWH as well as advocacy organizations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MANAGEMENT GUIDELINES
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HEMOPHILIA
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GENETICS
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DIAGNOSIS-THERAPY
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Hematología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
WFH Guidelines for the Management of Hemophilia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-27T20:25:03Z
dc.identifier.eissn
1365-2516
dc.journal.volume
26
dc.journal.number
S6
dc.journal.pagination
1-158
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Srivastava, Alok. Christian Medical College, Vellore; India
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Fil: Santagostino, Elena. Maggiore Hospital Policlinico; Suiza
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Fil: Dougall, Alison. Dublin Dental University Hospital; Irlanda
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Fil: Kitchen, Steve. Sheffield Teaching Hospitals NHS Foundation Trust; Reino Unido
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Fil: Sutherland, Megan. Manchester University Nhs Foundation Trust; Reino Unido
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Fil: Pipe, Steven W.. University of Michigan; Estados Unidos
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Fil: Carcao, Manuel. University Of Toronto. Hospital For Sick Children; Canadá
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Fil: Mahlangu, Johnny. University of the Witwatersrand; Sudáfrica
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Fil: Ragni, Margaret V.. University of Pittsburgh; Estados Unidos
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Fil: Windyga, Jerzy. Institute of Hematology and Transfusion Medicine; Polonia
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Fil: Llinás, Adolfo. Universidad de los Andes; Colombia
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Fil: Goddard, Nicholas J.. The Royal Free Hospital; Reino Unido
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Fil: Mohan, Richa. Empowering Minds Society For Research And Development; India
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Fil: Poonnoose, Pradeep M.. Christian Medical College; India
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Fil: Feldman, Brian M.. University Of Toronto. Hospital For Sick Children; Canadá
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Fil: Lewis, Sandra Zelman. EBQ Consulting; Estados Unidos
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Fil: van den Berg, H. Marijke. Pednet Haemophilia Research Foundation; Países Bajos
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Fil: Pierce, Glenn F.. World Federation Of Hemophilia; Canadá
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Fil: de Brasi, Carlos Daniel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Haemophilia The Official Journal Of The World Federation Of Hemophilia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/hae.14046
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/hae.14046
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