Artículo

A formal total synthesis of the marine alkaloid aaptamine

Larghi, Enrique LeandroIcon ; Obrist, Blaise V.; Kaufman, Teodoro SaulIcon
Fecha de publicación: 05/2008
Editorial: Pergamon-Elsevier Science Ltd
Revista: Tetrahedron
ISSN: 0040-4020
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.
Palabras clave: 2,3,3A,4,5,6-HEXAHYDROAAPTAMINE , AAPTAMINE , BENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDS , FORMAL TOTAL SYNTHESIS
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/136903
URL: https://www.sciencedirect.com/science/article/abs/pii/S0040402008005486
DOI: https://doi.org/10.1016/j.tet.2008.03.036
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Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul; A formal total synthesis of the marine alkaloid aaptamine; Pergamon-Elsevier Science Ltd; Tetrahedron; 64; 22; 5-2008; 5236-5245
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