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dc.contributor.author
Vignaduzzo, Silvana Edit  
dc.contributor.author
Maggio, Ruben Mariano  
dc.contributor.author
Castellano, Patricia Margarita  
dc.contributor.author
Kaufman, Teodoro Saul  
dc.date.available
2021-07-21T12:09:05Z  
dc.date.issued
2005-07  
dc.identifier.citation
Vignaduzzo, Silvana Edit; Maggio, Ruben Mariano; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies; Springer Heidelberg; Analytical and Bioanalytical Chemistry; 382; 7; 7-2005; 1711-1714  
dc.identifier.issn
1618-2642  
dc.identifier.uri
http://hdl.handle.net/11336/136549  
dc.description.abstract
A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer Heidelberg  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ACETAMINOPHEN  
dc.subject
CHEMOMETRIC METHOD  
dc.subject
DICLOFENAC  
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DISSOLUTION  
dc.subject
PLS  
dc.subject.classification
Química Orgánica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-06-07T16:16:37Z  
dc.journal.volume
382  
dc.journal.number
7  
dc.journal.pagination
1711-1714  
dc.journal.pais
Alemania  
dc.journal.ciudad
Heidelberg  
dc.description.fil
Fil: Vignaduzzo, Silvana Edit. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
dc.description.fil
Fil: Maggio, Ruben Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Castellano, Patricia Margarita. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina  
dc.description.fil
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.journal.title
Analytical and Bioanalytical Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00216-005-3314-1  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00216-005-3314-1  

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