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dc.contributor.author
Sassetti, Fernando
dc.contributor.author
Guarnieri, Fabio Ariel
dc.contributor.author
Garelli, Luciano
dc.contributor.author
Storti, Mario Alberto
dc.date.available
2017-03-06T18:17:28Z
dc.date.issued
2011-08
dc.identifier.citation
Sassetti, Fernando; Guarnieri, Fabio Ariel; Garelli, Luciano; Storti, Mario Alberto; Characterisation and simulation of an active microvalve for glaucoma ; Taylor & Francis Ltd; Computer Methods In Biomechanics And Biomedical Engineering; 8-2011
dc.identifier.issn
1025-5842
dc.identifier.uri
http://hdl.handle.net/11336/13560
dc.description.abstract
Glaucoma drainage device (GDD) has the potential to eliminate hypotony but still suffers from poor flow control and fibrosis. The ideal shunt should change its hydraulic resistance to achieve the desired intraocular pressure (IOP). In this study, the characterisation of a preliminary design of a new GDD is presented. This is activated by means of a diaphragm, which is actuated by conducting polymers. The valve can be manufactured employing microelectromechanical system technology by soft lithography. The characterisation process is performed by numerical simulation using the finite element method, considering the coupling between the fluid and the structure (diaphragm) obtaining the hydraulic resistance for several positions of the diaphragm. To analyse the hydraulic system of the microvalve implanted in a human eye, an equivalent circuit model was used. The parameters of the equivalent circuit model were obtained from numerical simulation. The hydraulic resistance of the designed GDD varies in the range of 13.08–0.36 mmHg min/μl compared with 3.38–0.43 mmHg min/μl for the Ahmed valve. The maximum displacement of the diaphragm in the vertical direction is 18.9 μm, and the strain in the plane is 2%. The proposed preliminary design allows to control the IOP by varying the hydraulic resistance in a greater range than the existing passive valves, and the numerical simulation facilitates the characterisation and the improvement of the design before its construction, reducing time and costs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mecánica de Fluidos Computacional
dc.subject.classification
Otras Ingeniería Mecánica
dc.subject.classification
Ingeniería Mecánica
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Characterisation and simulation of an active microvalve for glaucoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-01T17:49:32Z
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Sassetti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional de Entre Rios. Facultad de Ingenieria. Departamento de Bioingenieria; Argentina
dc.description.fil
Fil: Guarnieri, Fabio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional de Entre Rios. Facultad de Ingenieria. Departamento de Bioingenieria; Argentina
dc.description.fil
Fil: Garelli, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional de Entre Rios. Facultad de Ingenieria. Departamento de Bioingenieria; Argentina
dc.description.fil
Fil: Storti, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
dc.journal.title
Computer Methods In Biomechanics And Biomedical Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1080/10255842.2011.585978


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