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dc.contributor.author
Barrantes, Francisco Jose  
dc.date.available
2021-07-02T13:20:48Z  
dc.date.issued
2021-05  
dc.identifier.citation
Barrantes, Francisco Jose; The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19; Annual Reviews; Annual Review Of Biophysics; 50; 5-2021; 493-523  
dc.identifier.issn
1936-122X  
dc.identifier.uri
http://hdl.handle.net/11336/135374  
dc.description.abstract
Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a hijacking mechanism perfected over the course of evolution. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has successfully adopted this strategy using its spike glycoprotein to dock on the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2). The crystal structures of several SARS-CoV-2 proteins alone or in complex with their receptors or other ligands were recently solved at an unprecedented pace. This accomplishment is partly due to the increasing availability of data on other coronaviruses and ACE2 over the past 18 years. Likewise, other key intervening actors and mechanisms of viral infection were elucidated with the aid of biophysical approaches. An understanding of the various structurally important motifs of the interacting partners provides key mechanistic information for the development of structure-based designer drugs able to inhibit various steps of the infective cycle, including neutralizing antibodies, small organic drugs, and vaccines. This review analyzes current progress and the outlook for future structural studies.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Annual Reviews  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ACE2  
dc.subject
COVID-19  
dc.subject
CRYO-ELECTRON MICROSCOPY  
dc.subject
SARS-COV-2  
dc.subject
VIRUS-RECEPTOR INTERACTIONS  
dc.subject
X-RAY DIFFRACTION  
dc.subject.classification
Biofísica  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-07-02T12:51:24Z  
dc.journal.volume
50  
dc.journal.pagination
493-523  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina  
dc.journal.title
Annual Review Of Biophysics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1146/annurev-biophys-102620-080956  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/10.1146/annurev-biophys-102620-080956