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dc.contributor.author
Pellegrini, Gretel Gisela
dc.contributor.author
González Chaves, Macarena
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Zeni Coronel, Estefania Magali
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Avendaño, María Eugenia
dc.contributor.author
Bonanno, Marina Soledad
dc.contributor.author
Zeni, Susana Noemi
dc.date.available
2021-07-01T11:49:03Z
dc.date.issued
2020-12
dc.identifier.citation
Pellegrini, Gretel Gisela; González Chaves, Macarena; Zeni Coronel, Estefania Magali; Avendaño, María Eugenia; Bonanno, Marina Soledad; et al.; Levels of Bone Turnover in Saliva Correlated with Antirresortive Treatment: Experimental Study; Austin Publishing Group; Austin Journal of Dentistry; 7; 12-2020; 1-5
dc.identifier.uri
http://hdl.handle.net/11336/135236
dc.description.abstract
Background: Bone turnover markers are useful to evaluate bone loss and monitor anticatabolic treatments in a short period. The effectiveness of saliva to reflect changes in bone turnover markers during the early administration of different doses of olpadronate (POD) (4 mg or 8 mg/100 g body weight), immediately after Ovariectomy (OVX), was evaluated.Material and Methods: Adult rats (n=10/group) were divided and treated as follows for 45 days: SHAM+Vh; OVX+Vh; OVX+4OPD and OVX+8OPD. To validate the model, Proximal Tibia Bone Mineral Density (PTBMD) change between the beginning and the end of the study. Blood and saliva were collected post-surgery (t=0; t=10; t=20; t=45).Results: PTBMD decrease in OVX+Vh was partially prevented by 4OPD and avoided by 8OPD. Salivary and serum β-CrossLaps (CTX) in SHAM+Vh remained without changes and increased in OVX+Vh (p<0.05); Bone-Specific Alkaline Phosphatase (B-ALP) increased in OVX+Vh versus SHAM+Vh reaching signicance at t=20 (p< 0.05). A dose-dependent response was observed insalivary and serum CTX and B-ALP by OPD treatment (p<0.05). CTX was lower in OVX+8OPD versus OVX+4OPD from t=10 in serum samples and from t=20 in salivary samples (p<0.05) while B-ALP reached lower levels at t=45 (p<0.05).Conclusion: Although further clinical studies are needed, our results suggest that CTX and B-ALP in saliva decreased by Bisphosphonate (BP) therapy in a dose dependent manner. Therefore, saliva would be a suitable tool for evaluating changes in bone turnover due to BP therapy in the early stage of estrogen withdrawal.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Austin Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BONE TURNOVER MARKERS
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OSTEOPOROSIS
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SALIVA
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ESTROGEN WITHDRAWAL
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BISPHOSPHONATE
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Levels of Bone Turnover in Saliva Correlated with Antirresortive Treatment: Experimental Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T19:51:18Z
dc.identifier.eissn
2381-9189
dc.journal.volume
7
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Texas
dc.description.fil
Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Columbia University. Center For Science And Society.; Estados Unidos
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Fil: González Chaves, Macarena. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Zeni Coronel, Estefania Magali. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Avendaño, María Eugenia. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Bonanno, Marina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.journal.title
Austin Journal of Dentistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/dentistry/download.php?file=fulltext/jd-v7-id1145.pdf
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