Artículo
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Lorenzo Martín, L. Francisco; Fernández Parejo, Natalia; Menacho Márquez, Mauricio Ariel
; Rodríguez Fdez, Sonia; Robles Valero, Javier; Zumalave, Sonia; Fabbiano, Salvatore; Pascual Angulo, Gloria; García Pedrero, Juana M.; Abad, Antonio; García Macías, María Carmen; González, Nazareno
; Lorenzano Menna, Pablo
; Pavón, Miguel A.; González Sarmiento, Rogelio; Segrelles, Carmen; Paramio, Jesús M.; Tubío, José M. C.; Rodrigo, Juan Pablo; Benitah, Salvador Aznar; Cuadrado, Myriam; Bustelo, Xosé R.
Fecha de publicación:
12/2020
Editorial:
Nature Research
Revista:
Nature Communications
ISSN:
2041-1723
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-characterized. Here, we show that those traits can be triggered by the RHO GTPase activator VAV2 in keratinocytes present in the skin and oral mucosa. VAV2 is also required to maintain those traits in hnSCC patient-derived cells. This function, which is both catalysis- and RHO GTPase-dependent, is mediated by c-Myc- and YAP/TAZ-dependent transcriptomal programs associated with regenerative proliferation and cell undifferentiation, respectively. High levels of VAV2 transcripts and VAV2-regulated gene signatures are both associated with poor hnSCC patient prognosis. These results unveil a druggable pathway linked to the malignancy of specific SCC subtypes.
Palabras clave:
CANCER MODELS
,
RHO SIGNALLING
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IDICER)
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Lorenzo Martín, L. Francisco; Fernández Parejo, Natalia; Menacho Márquez, Mauricio Ariel; Rodríguez Fdez, Sonia; Robles Valero, Javier; et al.; VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma; Nature Research; Nature Communications; 11; 4788; 12-2020; 1-21
Compartir
Altmétricas