Artículo
Crystal structure of a lapacholate complex with Co(II), a potential antibacterial pharmaceutical
Farfán, Ramón A.; Espíndola, José Alfredo; Gómez, María Inés; Audisio, Marcela Carina
; Britos Fabian, Maria Luciana
; Castellano, Eduardo Ernesto; Piro, Oscar Enrique
Fecha de publicación:
15/03/2019
Editorial:
Elsevier Science
Revista:
Journal of Molecular Structure
ISSN:
0022-2860
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The solid state molecular structure of dilapacholate diaquo cobalt (II) di-dimethylformamide, for short [Co(Lap) 2 (H 2 O) 2 ]·2DMF, was determined by X-ray diffraction methods. It crystallizes in the monoclinic space group P2 1 /n with Z = 2 molecules per unit cell. The complex is at a crystallographic inversion centre with the Co (II) ion in a distorted octahedral environment of approximate D 2h local symmetry, coordinated to two lapacholate anions acting as bidentate ligands through their carbonyl and phenolic oxygen atoms, and to two water molecules nearly along the bisector of their oxygen electron lone-pair lobes. The IR absorption spectrum, electronic absorption, TGA data and also a comparison of IR characteristic bands with the corresponding ones of other Co-lapacholates are also discussed. At a concentration of 25 ppm, the new metal complex shows biological activity against several clinical Staphylococcus aureus strains.
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Articulos(IFLP)
Articulos de INST.DE FISICA LA PLATA
Articulos de INST.DE FISICA LA PLATA
Citación
Farfán, Ramón A.; Espíndola, José Alfredo; Gómez, María Inés; Audisio, Marcela Carina; Britos Fabian, Maria Luciana; et al.; Crystal structure of a lapacholate complex with Co(II), a potential antibacterial pharmaceutical; Elsevier Science; Journal of Molecular Structure; 1180; 15-3-2019; 792-797
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