Artículo
Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites
Vargas, Gabriela Elizabet
; Haro Durand, Luis Alberto
; Cadena, María Vanesa
; Romero, Marcela; Vera Mesones, Rosa; Mačković, Mirza; Spallek, Stefanie; Spiecker, Erdmann; Boccaccini, Aldo R.; Gorustovich Alonso, Alejandro Adrian
Fecha de publicación:
22/02/2013
Editorial:
Springer
Revista:
Journal of Materials Science: Materials In Medicine
ISSN:
0957-4530
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Angiogenesis is essential for tissue regeneration and repair. A growing body of evidence shows that the use of bioactive glasses (BG) in biomaterial-based tissue engineering (TE) strategies may improve angiogenesis and induce increased vascularization in TE constructs. This work investigated the effect of adding nano-sized BG particles (n-BG) on the angiogenic properties of bovine type I collagen/n-BG composites. Nano-sized (20-30 nm) BG particles of nominally 45S5 Bioglass composition were used to prepare composite films, which were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The in vivo angiogenic response was evaluated using the quail chorioallantoic membrane (CAM) as an model of angiogenesis. At 24 h post-implantation, 10 wt% n-BG containing collagen films stimulated angiogenesis by increasing by 41 % the number of blood vessels branch points. In contrast, composite films containing 20 wt% n-BG were found to inhibit angiogenesis. This experimental study provides the first evidence that addition of a limited concentration of n-BG (10 wt%) to collagen films induces an early angiogenic response making selected collagen/n-BG composites attractive matrices for tissue engineering and regenerative medicine.
Palabras clave:
NANO-SIZED BIOACTIVE GLASS
,
COLLAGEN
,
COMPOSITES
,
ANGIOGENESIS
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Identificadores
Colecciones
Articulos(CCT - SALTA-JUJUY)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SALTA-JUJUY
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SALTA-JUJUY
Citación
Vargas, Gabriela Elizabet; Haro Durand, Luis Alberto; Cadena, María Vanesa; Romero, Marcela; Vera Mesones, Rosa; et al.; Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites; Springer; Journal of Materials Science: Materials In Medicine; 24; 5; 22-2-2013; 1261-1269
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