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dc.contributor.author
Sampieri, Luciana
dc.contributor.author
Di Giusto, Pablo
dc.contributor.author
Alvarez, Cecilia Ines
dc.date.available
2021-03-18T20:05:33Z
dc.date.issued
2019-07
dc.identifier.citation
Sampieri, Luciana; Di Giusto, Pablo; Alvarez, Cecilia Ines; CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis; Frontiers Media S.A.; Frontiers in Cell and Developmental Biology; 7; 7-2019
dc.identifier.uri
http://hdl.handle.net/11336/128585
dc.description.abstract
CREB3 family of transcription factors are ER localized proteins that belong to the bZIP family. They are transported from the ER to the Golgi, cleaved by S1P and S2P proteases and the released N-terminal domains act as transcription factors. CREB3 family members regulate the expression of a large variety of genes and according to their tissue-specific expression profiles they play, among others, roles in acute phase response, lipid metabolism, development, survival, differentiation, organelle autoregulation, and protein secretion. They have been implicated in the ER and Golgi stress responses as regulators of the cell secretory capacity and cell specific cargos. In this review we provide an overview of the diverse functions of each member of the family (CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4) with special focus on their role in the central nervous system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media S.A.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CELLULAR HOMEOSTASIS
dc.subject
CENTRAL NERVOUS SYSTEM
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CREB3 TRANSCRIPTION FACTORS
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ER STRESS RESPONSE
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GOLGI STRESS RESPONSE
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SECRETORY CAPACITY
dc.subject
SECRETORY PATHWAY
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
CREB3 transcription factors: ER-golgi stress transducers as hubs for cellular homeostasis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-25T17:51:00Z
dc.identifier.eissn
2296-634X
dc.journal.volume
7
dc.journal.pais
Suiza
dc.journal.ciudad
Lausana
dc.description.fil
Fil: Sampieri, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Di Giusto, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Alvarez, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Frontiers in Cell and Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fcell.2019.00123/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fcell.2019.00123
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