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dc.contributor.author
Ortiz Moyano, Francisco Ramiro

dc.contributor.author
Raya Tonetti, María Fernanda

dc.contributor.author
Tomokiyo, Mikado
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Kanmani, Paulraj

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Vizoso Pinto, María Guadalupe

dc.contributor.author
Kim, Hojun

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Quilodrán Vega, Sandra

dc.contributor.author
Melnikov, Vyacheslav

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Alvarez, Gladis Susana

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Takahashi, Hideki

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Kurata, Shoichiro
dc.contributor.author
Kitazawa, Haruki

dc.contributor.author
Villena, Julio Cesar

dc.date.available
2021-03-03T12:31:16Z
dc.date.issued
2020-05
dc.identifier.citation
Ortiz Moyano, Francisco Ramiro; Raya Tonetti, María Fernanda; Tomokiyo, Mikado; Kanmani, Paulraj; Vizoso Pinto, María Guadalupe; et al.; The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic; Multidisciplinary Digital Publishing Institute; Microorganisms; 8; 5; 5-2020; 1-23;727-727
dc.identifier.issn
2076-2607
dc.identifier.uri
http://hdl.handle.net/11336/127236
dc.description.abstract
We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CORYNEBACTERIUM PSEUDODIPHTHERITICUM
dc.subject
TLR2
dc.subject
INNATE IMMUNITY
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RESPIRATORY COMMENSAL BACTERIA
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DOLOSIGRANULUM PIGRUM
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TLR3
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RESPIRATORY SYNCYTIAL VIRUS
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STREPTOCOCCUS PNEUMONIAE
dc.subject.classification
Biología Celular, Microbiología

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Ciencias Biológicas

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CIENCIAS NATURALES Y EXACTAS

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Enfermedades Infecciosas

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Ciencias de la Salud

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CIENCIAS MÉDICAS Y DE LA SALUD

dc.title
The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-02T20:16:30Z
dc.identifier.eissn
2076-2607
dc.journal.volume
8
dc.journal.number
5
dc.journal.pagination
1-23;727-727
dc.journal.pais
Suiza

dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Ortiz Moyano, Francisco Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Raya Tonetti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
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Fil: Tomokiyo, Mikado. Tohoku University; Japón
dc.description.fil
Fil: Kanmani, Paulraj. Dongguk University; Corea del Sur
dc.description.fil
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
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Fil: Kim, Hojun. Dongguk University; Corea del Sur
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Fil: Quilodrán Vega, Sandra. Universidad de Concepción; Chile
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Fil: Melnikov, Vyacheslav. Gabrichevsky Research Institute; Rusia
dc.description.fil
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Takahashi, Hideki. Tohoku University; Japón
dc.description.fil
Fil: Kurata, Shoichiro. Tohoku University; Japón
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.journal.title
Microorganisms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/microorganisms8050727
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/8/5/727
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