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dc.contributor.author
Atkins, Paul W.
dc.contributor.author
Perez, Hernán A.
dc.contributor.author
Spence, John David
dc.contributor.author
Muñoz, Sonia Edith
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dc.contributor.author
Armando, Luis J.
dc.contributor.author
Garcia, Nestor Horacio
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dc.date.available
2021-02-12T15:27:15Z
dc.date.issued
2019-11
dc.identifier.citation
Atkins, Paul W.; Perez, Hernán A.; Spence, John David; Muñoz, Sonia Edith; Armando, Luis J.; et al.; Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors; Termedia Publishing House Ltd; Archives Of Medical Science; 15; 6; 11-2019; 1388-1396
dc.identifier.issn
1734-1922
dc.identifier.uri
http://hdl.handle.net/11336/125586
dc.description.abstract
Introduction: The hypothesis that relates atherosclerosis to traditional risk factors (TRF) seems to be not as adequate as previously thought; other risk factors (RF) need to be considered to prevent atherosclerosis progression. Although a family medical history of premature cardiovascular events (FHx) has been considered the putative RF for decades, it has not been incorporated routinely into cardiovascular risk evaluation along with another RF. The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: Hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI) > 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05). A second analysis performed in hypertensive patients but no other TRF; 32 patients with FHx were identified. Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05). A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls. Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF. This supports ultrasound screening in FHx patients in order to detect high-risk patients who may benefit from early intervention.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Termedia Publishing House Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATHEROSCLEROSIS
dc.subject
CARDIOVASCULAR DISEASE
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FAMILY HISTORY
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PLAQUE
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RISK FACTORS
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Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:10:37Z
dc.identifier.eissn
1896-9151
dc.journal.volume
15
dc.journal.number
6
dc.journal.pagination
1388-1396
dc.journal.pais
Polonia
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dc.description.fil
Fil: Atkins, Paul W.. Western University; Canadá
dc.description.fil
Fil: Perez, Hernán A.. Blossom Dmo; Argentina
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Fil: Spence, John David. Robarts Research Institute; Canadá
dc.description.fil
Fil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil
Fil: Armando, Luis J.. Blossom Dmo; Argentina
dc.description.fil
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.journal.title
Archives Of Medical Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5114/aoms.2019.84677
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.archivesofmedicalscience.com/Increased-carotid-plaque-burden-in-patients-with-family-medical-history-of-premature,89692,0,2.html
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