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dc.contributor.author
Files, D. Clark
dc.contributor.author
Liu, Chun
dc.contributor.author
Pereyra, Andrea Soledad
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Wang, Zhong Min
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Aggarwal, Neil
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D´Alessio, Franco
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Garibaldi, Brian T.
dc.contributor.author
Mock, Jason R.
dc.contributor.author
Singer, Benjamin D.
dc.contributor.author
Feng, Xin
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Yammani, Raghunatha R.
dc.contributor.author
Zhang, Tan
dc.contributor.author
Lee, Amy L.
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Philpott, Sydney
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Lussier, Stephanie
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Purcell, Lina
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Chou, Jeff
dc.contributor.author
Seeds, Michael
dc.contributor.author
King, Landon S.
dc.contributor.author
Morris, Peter E.
dc.contributor.author
Delbono, Osvaldo
dc.date.available
2021-02-08T14:37:12Z
dc.date.issued
2015-03
dc.identifier.citation
Files, D. Clark; Liu, Chun; Pereyra, Andrea Soledad; Wang, Zhong Min; Aggarwal, Neil; et al.; Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting; American Association for the Advancement of Science; SCIENCE TRANSLATIONAL MEDICINE; 7; 278; 3-2015; 278-310
dc.identifier.issn
1946-6234
dc.identifier.uri
http://hdl.handle.net/11336/125093
dc.description.abstract
Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association for the Advancement of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LUNG INJURY
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EXERCISE
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SKELETAL MUSCLE WASTING
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-03-18T20:34:59Z
dc.journal.volume
7
dc.journal.number
278
dc.journal.pagination
278-310
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Files, D. Clark. School Of Medicine; Estados Unidos
dc.description.fil
Fil: Liu, Chun. School Of Medicine; Estados Unidos
dc.description.fil
Fil: Pereyra, Andrea Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
dc.description.fil
Fil: Wang, Zhong Min. University Wake Forest; Estados Unidos. School Of Medicine; Estados Unidos
dc.description.fil
Fil: Aggarwal, Neil. Johns Hopkins Asthma And Allergy Center; Estados Unidos
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Fil: D´Alessio, Franco. Johns Hopkins Asthma And Allergy Center; Estados Unidos
dc.description.fil
Fil: Garibaldi, Brian T.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
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Fil: Mock, Jason R.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
dc.description.fil
Fil: Singer, Benjamin D.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
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Fil: Feng, Xin. Wake Forest School of Medicine; Estados Unidos
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Fil: Yammani, Raghunatha R.. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Zhang, Tan. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Lee, Amy L.. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Philpott, Sydney. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Lussier, Stephanie. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Purcell, Lina. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Chou, Jeff. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Seeds, Michael. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: King, Landon S.. Johns Hopkins Asthma and Allergy Center; Estados Unidos
dc.description.fil
Fil: Morris, Peter E.. Wake Forest School of Medicine; Estados Unidos
dc.description.fil
Fil: Delbono, Osvaldo. School Of Medicine; Estados Unidos
dc.journal.title
SCIENCE TRANSLATIONAL MEDICINE
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://stm.sciencemag.org/content/7/278/278ra32
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/scitranslmed.3010283
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820823/
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