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dc.contributor.author
Santibáñez, M.
dc.contributor.author
Vásquez, M.
dc.contributor.author
Silva, A.
dc.contributor.author
Malano, Francisco Mauricio
dc.contributor.author
Valente, Mauro Andres
dc.contributor.author
Figueroa, R. G.
dc.date.available
2021-01-29T18:52:12Z
dc.date.issued
2019-09
dc.identifier.citation
Santibáñez, M.; Vásquez, M.; Silva, A.; Malano, Francisco Mauricio; Valente, Mauro Andres; et al.; A high-sensitivity and low dose energy-dispersive X-ray fluorescence system for identification of gadolium accumulations in planar X-ray fluorescence images; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 151; 9-2019; 46-51
dc.identifier.issn
0969-8043
dc.identifier.uri
http://hdl.handle.net/11336/124266
dc.description.abstract
A new technique, based on in-vivo energy dispersive X-ray fluorescence (EDXRF), has been developed to gadolinium (Gd)concentrations identification in planar X-ray fluorescence (XRF)images. Higher signal-to-noise (SNR)ratios while keeping a low radiation dose were achieved. Experimental validation was performed using tissue equivalent phantoms under two different data acquisition criteria. The first criteria consisted on acquiring the energy spectra from different experimental narrow spectrum beam (FWHM = 2.5 keV)with peak central energy above the L edge energy and determining the spectrum which producing Lowest-Limit-of-Detection (Lowest-LoD)for a specific acquisition time. This also provided the minimum dose expected under the condition of minimum irradiation time. The second criteria consisted on measuring the surface dose required to obtain a specific LoD by different narrow spectrum beam, providing the Lowest-Dose setting. Surface (2D)Gd-doped tissue-equivalent phantoms scanning were performed according to optimized scenarios: Lowest-LoD setting (obtaining to central energy of 10.9 keV)and Lowest-Dose setting (obtaining to central energy 12.9 keV). 625 pixel images were acquired in two different conditions: a pre-defined time (5 s)per pixel was set in the first approach, whereas a pre-defined total surface dose (4 mGy)was set to the second approach. According to the results obtained for the first approach, a 58 times reduction was observed when comparing SNR between the Lowest-LoD and Lowest-Dose settings. On the other hand, for the second approach pre-defining total dose during the whole examination, the best SNR was obtained for the Lowest-Dose configuration exhibiting a 42% of increment respecting to the Lowest-LoD configuration and 47 times higher when compared with the limit case of no optimization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IN VIVO 2D EDXRF IMAGING
dc.subject
NON-INVASIVE IN-PHANTOM GADOLINIUM MAPPING
dc.subject.classification
Física Atómica, Molecular y Química
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A high-sensitivity and low dose energy-dispersive X-ray fluorescence system for identification of gadolium accumulations in planar X-ray fluorescence images
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:27:11Z
dc.journal.volume
151
dc.journal.pagination
46-51
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Santibáñez, M.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Vásquez, M.. Centro Oncológico Antofagasta; Chile
dc.description.fil
Fil: Silva, A.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Malano, Francisco Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
dc.description.fil
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
dc.description.fil
Fil: Figueroa, R. G.. Universidad de La Frontera; Chile
dc.journal.title
Applied Radiation and Isotopes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.apradiso.2019.05.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S096980431930260X
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