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dc.contributor.author
Kanmani, Paulraj
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dc.contributor.author
Ansari, AbuZar
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dc.contributor.author
Villena, Julio Cesar
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dc.contributor.author
Kim, Hojun
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dc.date.available
2021-01-05T21:15:32Z
dc.date.issued
2019-03-14
dc.identifier.citation
Kanmani, Paulraj; Ansari, AbuZar; Villena, Julio Cesar; Kim, Hojun; Immunobiotics beneficially modulate TLR4 signaling triggered by lipopolysaccharide and reduce hepatic steatosis in vitro; Hindawi Publishing Corporation; Journal of Immunology Research; 2019; 14-3-2019; 1-12;3876896-3876896
dc.identifier.issn
2314-8861
dc.identifier.uri
http://hdl.handle.net/11336/121568
dc.description.abstract
Hepatic inflammation and injury may result from the translocation of pathological bacteria and their proinflammatory mediators. Probiotics attenuate hepatic diseases related to inflammation by exhibiting immunoregulatory effects. Therefore, this study was conducted to evaluate lipid reduction and immunoregulatory potentials of probiotic bacteria in vitro. HepG2 cells treated with total cellular fluid (TCF) of LABs reduced lipid accumulation. Moreover, cells responded to lipopolysaccharide (LPS) by producing higher levels of IL-6, IL-8, MCP-1, and TNF-α. TCF of LABs treatment showed remarkably diminished levels of the expression of these cytokines via modulation of the expression of TLR-negative regulators, as well as MAPK and NF-κB pathways. Moreover, heat-killed LABs were able to diminish TGF-β, IL-1β, and IL-6 and to increase IL-10 and TLR4 levels in THP-1 cells. LABs also decreased the protein level of TNF-α. These results demonstrated that immunobiotics exhibit potent immunoregulatory activity and may be used as effective therapeutic agents to alleviate inflammatory response.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
IMMUNOBIOTICS
dc.subject
TLR4
dc.subject
LIPOPOLYSACCHARIDE
dc.subject
HEPATIC STEATOSIS
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immunobiotics beneficially modulate TLR4 signaling triggered by lipopolysaccharide and reduce hepatic steatosis in vitro
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-02T20:16:04Z
dc.identifier.eissn
2314-7156
dc.journal.volume
2019
dc.journal.pagination
1-12;3876896-3876896
dc.journal.pais
Egipto
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dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Kanmani, Paulraj. Dongguk University; Corea del Sur
dc.description.fil
Fil: Ansari, AbuZar. Dongguk University; Corea del Sur
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Kim, Hojun. Dongguk University; Corea del Sur
dc.journal.title
Journal of Immunology Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2019/3876896
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2019/3876896/
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