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Artículo

Antifouling activity of peracetylated cholic acid, a natural bile acid derivative

Pérez, Miriam; Sánchez, MarianelaIcon ; García, Mónica; Patiño Cano, Laura Patricia; Blustein, GuillermoIcon ; Palermo, Jorge AlejandroIcon
Fecha de publicación: 09/2019
Editorial: Elsevier Science Inc
Revista: Steroids
ISSN: 0039-128X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Orgánica

Resumen

The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in a previous work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated in laboratory and field trials. Toxicity and settlement assays were performed with the mussel Mytilus edulis platensis, while the field trials were carried out by addition of the compound to experimental soluble-matrix paints, which were then tested in the sea. The results obtained in this work show that 1 has a good antifouling activity and low toxicity, and the paints aditivated with 0,6% Wt showed promissory performances in the field trials at the sea. These results confirm the previous hypothesis that the few acetylated and lipophilic bile acid derivatives isolated from marine invertebrates may act as natural antifoulants. Compound 1 is a natural, biodegradable product that can be easily prepared from cholic acid, which in turn can be isolated in industrial scale from cattle bile. All these facts make cholic acid a good scaffold for the preparation of derivatives, which can be natural product-like, effective and sustainable antifouling additives for marine paints and other applications.
Palabras clave: ACETYLATED BILE ACIDS , ANTIFOULING ACTIVITY , MARINE INVERTEBRATES , SIPHONOCHALINA FORTIS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/121259
URL: https://linkinghub.elsevier.com/retrieve/pii/S0039128X19300984
DOI: https://doi.org/10.1016/j.steroids.2019.05.006
Colecciones
Articulos(CIDEPINT)
Articulos de CENTRO DE INV EN TECNOLOGIA DE PINTURAS (I)
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Pérez, Miriam; Sánchez, Marianela; García, Mónica; Patiño Cano, Laura Patricia; Blustein, Guillermo; et al.; Antifouling activity of peracetylated cholic acid, a natural bile acid derivative; Elsevier Science Inc; Steroids; 149; 108414; 9-2019; 1-22
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