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dc.contributor.author
Politi, María Teresa
dc.contributor.author
Ochoa, Federico Claudio
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Netti, Vanina Alejandra
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Ferreyra, Raúl
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Bortman, Guillermo
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Sanjuan, Norberto Aníbal
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Morales, Celina
dc.contributor.author
Piazza, Antonio
dc.contributor.author
Capurro, Claudia Graciela
dc.date.available
2020-12-17T12:54:16Z
dc.date.issued
2019-09
dc.identifier.citation
Politi, María Teresa; Ochoa, Federico Claudio; Netti, Vanina Alejandra; Ferreyra, Raúl; Bortman, Guillermo; et al.; Changes in cardiac Aquaporin expression during aortic valve replacement surgery with cardiopulmonary bypass; Elsevier Science; European Journal Of Cardio-thoracic Surgery; 57; 3; 9-2019; 556-564
dc.identifier.issn
1010-7940
dc.identifier.uri
http://hdl.handle.net/11336/120714
dc.description.abstract
OBJECTIVES: Cardiopulmonary bypass (CPB) use is an essential strategy for many cardiovascular surgeries. However, its use and duration have been associated with a higher rate of postoperative complications, such as low cardiac output syndrome due to myocardial oedema and dysfunction. Though Aquaporin water channels have been implicated in myocardial water balance, their specific role in this clinical scenario has not been established. METHODS: In a consecutive study of 17 patients with severe aortic stenosis undergoing aortic valve replacement surgery, 2 myocardial biopsies of the left ventricle were taken: 1 before and 1 after CPB use. Sociodemographic, clinical and laboratory data were collected. Western blot and immunohistochemistry studies were performed. RESULTS: After CPB use, there was a mean increase of ∼62% in Aquaporin 1 protein levels (P = 0.001) and a mean reduction of ∼38% in Aquaporin 4 protein levels (P = 0.030). In immunohistochemistry assays, Aquaporin 1 was found lining small blood vessels, while Aquaporin 4 formed a circular label in cardiomyocytes. There were no changes in the localization of either protein following CPB use. During the observed on-pump time interval, there was a 1.7%/min mean increase in Aquaporin 1 (P = 0.021) and a 2.5%/min mean decrease in Aquaporin 4 (P = 0.018). Myocardial interstitial oedema increased by 42% (95% confidence interval 31-54%) after CPB use. Patients who developed low cardiac output syndrome were in the upper half of the median percentage change of Aquaporin expression. CONCLUSION: Time-dependent changes in cardiac Aquaporin expression may be associated with myocardial oedema and dysfunction related to CPB use.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AORTIC VALVE
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AQUAPORINS
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CARDIOPULMONARY BYPASS
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HUMANS
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MYOCARDIUM
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OEDEMA
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Changes in cardiac Aquaporin expression during aortic valve replacement surgery with cardiopulmonary bypass
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:35:50Z
dc.journal.volume
57
dc.journal.number
3
dc.journal.pagination
556-564
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Politi, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Ochoa, Federico Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Netti, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
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Fil: Ferreyra, Raúl. No especifíca;
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Fil: Bortman, Guillermo. No especifíca;
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Fil: Sanjuan, Norberto Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Morales, Celina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
dc.description.fil
Fil: Piazza, Antonio. No especifíca;
dc.description.fil
Fil: Capurro, Claudia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.journal.title
European Journal Of Cardio-thoracic Surgery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ejcts/advance-article/doi/10.1093/ejcts/ezz249/5571459
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ejcts/ezz249
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