Artículo
Detection of Taenia solium DNA in the urine of neurocysticercosis patients
Toribio, Luz; Romano, Miryam de Los Angeles
; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; Garcia, Hector H.; Shiff, Clive
Fecha de publicación:
06/2019
Editorial:
American Society of Tropical Medicine and Hygiene
Revista:
American Journal of Tropical Medicine and Hygiene
ISSN:
0002-9637
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Neurocysticercosis (NCC), caused by Taenia solium larvae that reside in the central nervous system, results in serious public health and medical issues in many regions of the world. Current diagnosis of NCC is complex requiring both serology and costly neuroimaging of parasitic cysts in the brain. This diagnostic pipeline can be problematic in resource-constrained settings. There is an unmet need for a highly sensitive and clinically informative diagnostic test to complement the present diagnostic approaches. Here, we report that T. solium–derived cell-free DNA is readily detectable in the urine of patients with the subarachnoid and parenchymal forms of NCC, and discuss the potential utility of this approach in enhancing and refining T. solium diagnostics.
Palabras clave:
TAENIA SOLIUM
,
REAL TIME PCR
,
NEUROCYSTICERCOSIS
,
DNA IN URINE
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Citación
Toribio, Luz; Romano, Miryam de Los Angeles; Scott, Alan L.; Gonzales, Isidro; Saavedra, Herbert; et al.; Detection of Taenia solium DNA in the urine of neurocysticercosis patients; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 100; 2; 6-2019; 327-329
Compartir
Altmétricas