Normal percentile curves for left atrial size in healthy children and adolescents

Abstract

Background: Despite the clinical utility of echocardiography to measure left atrial (LA) structure and function, there are scarcities of data about the percentiles of LA diameter (LAD), LA volume (LAVOL), and LA volume indexed by body surface area (LAVOL/BSA) from prospective population-based studies in healthy children and adolescents from the Southern Cone of Latin America. Methods: Echocardiographic studies were obtained in 1095 healthy subjects nonexposed to cardiovascular risk factors (5–24 years). Age- and sex-specific reference values of LAD, LAVOL, and LAVOL/BSA were generated using parametric regression based on fractional polynomials. Results: After covariate analysis (ie, adjusting by age, body surface area), specific sexspecific percentiles were evidenced as necessaries. Age- and sex-specific 1st, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile and curves were reported. Our percentiles showed high concordance and complementarity with what was previously reported for the population of North American, European, and Asiatic Populations. Conclusions: In children and adolescents, the interpretation of the LA size requires sex-related percentiles. This study provides the largest Argentinean database concerning percentile curves of LAD, LAVOL, and LAVOL/BSA obtained in healthy children and adolescents. These data are valuable in that they provide values with which data of populations of children, adolescents, and young adults can be compared.