Artículo
Vitamin D supplementation as a rational pharmacological approach in the covid-19 pandemic
Ferder, Leon Fernando; Martín Giménez, Virna Margarita
; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; Mariani, Javier; Manucha, Walter Ariel Fernando
Fecha de publicación:
09/2020
Editorial:
American Physiological Society
Revista:
American Journal Of Physiology-lung Cellular And Molecular Physiology
ISSN:
1040-0605
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The COVID-19 pandemic has reached most of the countries worldwide causing death, which often results from an inflammatory storm associated with severe acute respiratory syndrome (SARS). This has prompted researchers to seek specific novel and definitive treatments urgently. In this context, it is interesting to evaluate the preventive and therapeutic effects of existing pharmacological agents that could be useful. In this regard, vitamin D supplementation, particularly in individuals likely to be deficient, may be a promising option. Vitamin D is a hormone that modulates many of the same inflammatory and oxidative signaling pathways triggered during COVID-19. For example, vitamin D suppresses the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response related to COVID-19. This paper analyzes the evidence that vitamin D supplementation might be a valuable preventive/therapeutic measure in groups at risk of or infected with COVID-19. It also discusses how clinical studies could be best designed to evaluate the possible advantages of vitamin D supplementation for the benefit of public health during the pandemic.
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Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; et al.; Vitamin D supplementation as a rational pharmacological approach in the covid-19 pandemic; American Physiological Society; American Journal Of Physiology-lung Cellular And Molecular Physiology; 9-2020; 1-24
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