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dc.contributor.author
Roca Acevedo, Gonzalo
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dc.contributor.author
del Solar Kupfer, Carmen Paz
dc.contributor.author
Dressel Roa, Paulina
dc.contributor.author
Toloza, Ariel Ceferino
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dc.date.available
2020-11-04T13:42:42Z
dc.date.issued
2019-06
dc.identifier.citation
Roca Acevedo, Gonzalo; del Solar Kupfer, Carmen Paz; Dressel Roa, Paulina; Toloza, Ariel Ceferino; First Determination of Pyrethroid Knockdown Resistance Alleles in Human Head Lice (Phthiraptera: Pediculidae) from Chile; Entomological Society of America; Journal of Medical Entomology; 56; 6; 6-2019; 1698-1703
dc.identifier.issn
0022-2585
dc.identifier.uri
http://hdl.handle.net/11336/117586
dc.description.abstract
The infestation with the human ectoparasite, Pediculus humanus capitis (De Geer), is a common public health problem affecting schoolchildren worldwide. In Chile, the main active ingredients present in the over-the-counter pediculicides contain pyrethroids. Despite the extended use of these products, there is no evidence of the insecticide resistance status of the head lice geographically located in Chile. The most extended resistant mechanism of pyrethroids consists of the target site insensitivity (Kdr) determined by the presence of mutations linked to insecticide-binding sites in the voltage-sensitive sodium channel. T917I is recognized as the main mutation in head lice, and detection is considered to be a biomarker of resistance. The goal of the present study was to detect the presence and distribution of T917I mutation in five geographic locations of Chile. All five geographically selected louse populations had a frequency of pyrethroid resistance genes that ranged from 36 to 77%, and 94.9% of the collected head lice had one or two T917I mutant alleles. Moreover, the frequency of the aggregate resistant alleles was 50.5%. This is the first evidence that head lice in Chile had the mutations commonly associated with the resistance to pyrethroids. Moreover, the overrepresentation of heterozygotes in the studied populations suggests that head lice in Chile are currently under active selective pressure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Entomological Society of America
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEAD LICE
dc.subject
KDR
dc.subject
PEDICULOSIS
dc.subject
PEDICULUS HUMANUS CAPITIS
dc.subject
RESISTANCE
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
First Determination of Pyrethroid Knockdown Resistance Alleles in Human Head Lice (Phthiraptera: Pediculidae) from Chile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-10-22T18:24:34Z
dc.journal.volume
56
dc.journal.number
6
dc.journal.pagination
1698-1703
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Lanham
dc.description.fil
Fil: Roca Acevedo, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina
dc.description.fil
Fil: del Solar Kupfer, Carmen Paz. Liceteam; Chile
dc.description.fil
Fil: Dressel Roa, Paulina. Liceteam; Chile
dc.description.fil
Fil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina
dc.journal.title
Journal of Medical Entomology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jme/advance-article/doi/10.1093/jme/tjz101/5521013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/jme/tjz101
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