Mostrar el registro sencillo del ítem

dc.contributor.author
Medina, Vanina Araceli  
dc.contributor.author
Massari, Noelia Andrea  
dc.contributor.author
Cricco, Graciela Patricia  
dc.contributor.author
Martín, Gabriela A.  
dc.contributor.author
Bergoc, Rosa Maria  
dc.contributor.author
Rivera, Elena Susana  
dc.date.available
2020-09-17T17:11:59Z  
dc.date.issued
2009-06  
dc.identifier.citation
Medina, Vanina Araceli; Massari, Noelia Andrea; Cricco, Graciela Patricia; Martín, Gabriela A.; Bergoc, Rosa Maria; et al.; Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation; Elsevier Science Inc; Free Radical Biology and Medicine; 46; 11; 6-2009; 1510-1515  
dc.identifier.issn
0891-5849  
dc.identifier.uri
http://hdl.handle.net/11336/114226  
dc.description.abstract
Histamine is a recognized growth factor in melanoma, and exogenous histamine produces a dual effect on proliferation. We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines. To investigate the mechanism by which histamine inhibits proliferation of WM35 human melanoma cells, we have studied the involvement of histamine in reactive oxygen species production and antioxidant enzyme regulation in these cells. Results indicate that histamine treatment (10 μM) significantly increased hydrogen peroxide levels, whereas it slightly decreased superoxide levels associated with an enhancement of superoxide dismutase and a reduction in catalase activity. Additionally, catalase treatment reversed the inhibitory effect of histamine on proliferation, and various treatments that reduce hydrogen peroxide formation increased proliferation of these cells. Furthermore, we demonstrate that the inhibition of proliferation produced by histamine was mediated at least in part by an induction of cell senescence. We conclude that hydrogen peroxide is involved in histamine-mediated modulation of proliferation in malignant melanoma cells.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTIOXIDANT ENZYMES  
dc.subject
CELL PROLIFERATION  
dc.subject
FREE RADICALS  
dc.subject
HISTAMINE  
dc.subject
MELANOMA  
dc.subject
REACTIVE OXYGEN SPECIES  
dc.subject
SENESCENCE  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-09-08T14:04:47Z  
dc.journal.volume
46  
dc.journal.number
11  
dc.journal.pagination
1510-1515  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Massari, Noelia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Cricco, Graciela Patricia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Martín, Gabriela A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Bergoc, Rosa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.description.fil
Fil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina  
dc.journal.title
Free Radical Biology and Medicine  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0891584909001269  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.freeradbiomed.2009.03.003