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dc.contributor.author
Medina, Vanina Araceli
dc.contributor.author
Massari, Noelia Andrea
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Cricco, Graciela Patricia
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Martín, Gabriela A.
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Bergoc, Rosa Maria
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Rivera, Elena Susana
dc.date.available
2020-09-17T17:11:59Z
dc.date.issued
2009-06
dc.identifier.citation
Medina, Vanina Araceli; Massari, Noelia Andrea; Cricco, Graciela Patricia; Martín, Gabriela A.; Bergoc, Rosa Maria; et al.; Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation; Elsevier Science Inc; Free Radical Biology and Medicine; 46; 11; 6-2009; 1510-1515
dc.identifier.issn
0891-5849
dc.identifier.uri
http://hdl.handle.net/11336/114226
dc.description.abstract
Histamine is a recognized growth factor in melanoma, and exogenous histamine produces a dual effect on proliferation. We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines. To investigate the mechanism by which histamine inhibits proliferation of WM35 human melanoma cells, we have studied the involvement of histamine in reactive oxygen species production and antioxidant enzyme regulation in these cells. Results indicate that histamine treatment (10 μM) significantly increased hydrogen peroxide levels, whereas it slightly decreased superoxide levels associated with an enhancement of superoxide dismutase and a reduction in catalase activity. Additionally, catalase treatment reversed the inhibitory effect of histamine on proliferation, and various treatments that reduce hydrogen peroxide formation increased proliferation of these cells. Furthermore, we demonstrate that the inhibition of proliferation produced by histamine was mediated at least in part by an induction of cell senescence. We conclude that hydrogen peroxide is involved in histamine-mediated modulation of proliferation in malignant melanoma cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIOXIDANT ENZYMES
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CELL PROLIFERATION
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FREE RADICALS
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HISTAMINE
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MELANOMA
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REACTIVE OXYGEN SPECIES
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SENESCENCE
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-08T14:04:47Z
dc.journal.volume
46
dc.journal.number
11
dc.journal.pagination
1510-1515
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Massari, Noelia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Cricco, Graciela Patricia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Martín, Gabriela A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Bergoc, Rosa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Rivera, Elena Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Free Radical Biology and Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0891584909001269
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.freeradbiomed.2009.03.003
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