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dc.contributor.author
Rapanelli, Maximiliano
dc.contributor.author
Frick, Luciana Romina
dc.contributor.author
Miguelez Fernández, Anabel María Mercedes
dc.contributor.author
Zanutto, Bonifacio Silvano
dc.date.available
2016-12-27T20:35:26Z
dc.date.issued
2015-03-01
dc.identifier.citation
Rapanelli, Maximiliano; Frick, Luciana Romina; Miguelez Fernández, Anabel María Mercedes; Zanutto, Bonifacio Silvano; Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation.; Elsevier Science; Behavioural Brain Research; 280; 1-3-2015; 92-100
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/10345
dc.description.abstract
Dopamine encodes reward and its prediction in reinforcement learning. Catechol-O-methyltransferase (COMT) activity in the medial prefrontal cortex (mPFC) has been shown to influence cognitive abilities by modifying dopamine clearance. Nevertheless, it is unknown how COMT in the mPFC influences operant learning. Systemic entacapone (50mg/kg), as well as local entacapone (3pg) and recombinant COMT (17μg) in the mPFC were administered to male Long Evans rats prior to training in an operant conditioning task. We found that systemic and local administration of the COMT inhibitor entacapone significantly improves learning performance. Conversely, recombinant COMT administration totally impaired learning. These data have been interpreted through a computational model where the phasic firing of dopaminergic neurons was computed by means of a temporal difference algorithm and dopamine bioavailability in the mPFC was simulated with a gating window. The duration of this window was selected to simulate the effects of inhibited or enhanced COMT activity (by entacapone or recombinant COMT respectively). The model accounts for an improved performance reproducing the entacapone effects, and a detrimental impact on learning when the clearance is increased reproducing the recombinant COMT effects. The experimental and computational results show that learning performance can be deeply influenced by COMT manipulations in the mPFC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Comt
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Computational Model
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Dopamine
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Entacapone
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Neural Network
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Prefrontal Cortex
dc.subject.classification
Otras Ingeniería Médica
dc.subject.classification
Ingeniería Médica
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-04T19:25:10Z
dc.identifier.eissn
1872-7549
dc.journal.volume
280
dc.journal.pagination
92-100
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Rapanelli, Maximiliano. University Of Yale; Estados Unidos
dc.description.fil
Fil: Frick, Luciana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Miguelez Fernández, Anabel María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166432814007670
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2014.11.031