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dc.contributor.author
Rossi, Andrea Silvana
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dc.contributor.author
Lombardo, Yolanda B.
dc.contributor.author
Chicco, Adriana Graciela
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dc.date.available
2020-04-23T14:56:13Z
dc.date.issued
2010-02
dc.identifier.citation
Rossi, Andrea Silvana; Lombardo, Yolanda B.; Chicco, Adriana Graciela; Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil; Elsevier Science Inc; Nutrition; 26; 2; 2-2010; 209-217
dc.identifier.issn
0899-9007
dc.identifier.uri
http://hdl.handle.net/11336/103439
dc.description.abstract
Objective: The purposes of the present work were twofold: (1) investigate same mechanisms involvedin the development of fat cell hypertrophy in the experimental model of dyslipidemia andwhole-body insulin resistance induced in rats chronically fed a sucrose-rich diet (SRD); and (2) analyzethe possible beneficial effect of fish oil on these mechanisms.Methods: For 6 mo, male Wistar rats received a sucrose-rich diet (62.5% w/w sucrose, 8% corn oil)or a control diet in which sucrose was replaced by starch. After this period, the sucrose-fed animalswere divided randomly into two groups: the first one continued with the same diet up to 8 mo andthe second one received the same diet, but with corn oil replaced by 7% fish oil þ 1 % corn oil.Rats were fed with this diet for the next 2 mo.Results: Although an enlarged fat cell lipolysis and an impaired insulin-stimulated glucose uptakewere present in the fat cells of SRD-fed rats, an increase of several key enzymes of the novo lipogenesiscould be one of the possible mechanisms involved in visceral adiposity. The addition of dietaryfish oil restored or improved the above abnormalities.Conclusion: This study shows possible mechanisms conditioning the influence of nutrients on thedevelopment and management of dyslipidemia, insulin sensitivity, and fat cell accretion, all abnormalitiespresent in the metabolic syndrome.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADIPOSE TISSUE LIPOGENESIS
dc.subject
GLUCOSE UPTAKE
dc.subject
N-3 FATTY ACID
dc.subject
SUCROSE DIET
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Lipogenic enzyme activities and glucose uptake in fat tissue of dyslipemic, insulin-resistant rats: Effects of fish oil
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-21T15:19:11Z
dc.journal.volume
26
dc.journal.number
2
dc.journal.pagination
209-217
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Rossi, Andrea Silvana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
dc.description.fil
Fil: Lombardo, Yolanda B.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
dc.description.fil
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
dc.journal.title
Nutrition
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nut.2009.04.006
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