Artículo
Systemic oxidative stress associated with the neurological diseases of aging
Serra, Jorge Alberto
; Dominguez, Raul Omar
; Marschoff, Enrique Ricardo; Guareschi, Eduardo M.; Famulari, Arturo L.; Boveris, Alberto Antonio
Fecha de publicación:
12/2009
Editorial:
Springer/Plenum Publishers
Revista:
Neurochemical Research
ISSN:
0364-3190
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Markers of oxidative stress were measured in blood samples of 338 subjects (965 observations): Alzheimer´s, vascular dementia, diabetes (type II) superimposed to dementias, Parkinson´s disease and controls. Patients showed increased thiobarbituric acid reactive substances (+21%; P < 0.05), copper-zinc superoxide dismutase (+64%; P < 0.001) and decreased antioxidant capacity (-28%; P < 0.001); pairs of variables resulted linearly related across groups (P < 0.001). Catalase and glutathione peroxidase, involved in discrimination between diseases, resulted non-significant. When diabetes is superimposed with dementias, changes resulted less marked but significant. Also, superoxide dismutase resulted not linearly correlated with any other variable or age-related (pure Alzheimer´s peaks at 70 years, P < 0.001). Systemic oxidative stress was significantly associated (P 0.001) with all diseases indicating a disbalance in peripheral/adaptive responses to oxidative disorders through different free radical metabolic pathways. While other changes-methionine cycle, insulin correlation-are also associated with dementias, the responses presented here show a simple linear relation between prooxidants and antioxidant defenses.
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Colecciones
Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Serra, Jorge Alberto; Dominguez, Raul Omar; Marschoff, Enrique Ricardo; Guareschi, Eduardo M.; Famulari, Arturo L.; et al.; Systemic oxidative stress associated with the neurological diseases of aging; Springer/Plenum Publishers; Neurochemical Research; 34; 12; 12-2009; 2122-2132
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