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Artículo

Co-crystallization of zinc sulfate with sucrose: A promissory strategy to render zinc solid dosage forms more palatable

Lopez Cordoba, Alex FernandoIcon ; Gallo, Loreana CarolinaIcon ; Bucala, VeronicaIcon ; Martino, Miriam NoraIcon ; Navarro, Alba Sofia del RosarioIcon
Fecha de publicación: 02/2016
Editorial: Elsevier
Revista: Journal Of Food Engineering
ISSN: 0260-8774
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Alimentos y Bebidas

Resumen

The objective of this work was to develop solid dosage forms to improve zinc nutrition in high-risk populations. Powders containing zinc (17 mg/g) were obtained through co-crystallization in sucrose matrix with high encapsulation efficiency (98%). Co-crystallized powders showed water activity (0.6) and moisture content (2.0%) values characteristic of good stability. Moreover, these products showed an infrared spectrum similar to that of sucrose, indicating that no chemical interactions took place between the matrix components. Co-crystallized powders showed excellent compactibility leading to suitably hard compacts at a low compression force (4.9 kN). Besides, tablets were obtained with optimal values of hardness (4.8 kgf) and low disintegration times (<5 min) using blends of co-crystallized powder (80% w/ w), native corn starch (20% w/w) and magnesium stearate (1 g/100 g). The sensory evaluation of the tablets was performed obtaining a mean overall acceptability rating of 5, which corresponds to the neutral point of the hedonic scale used.
Palabras clave: Zinc , Co-Crystallization , Encapsulation , Solid Dosage Form , Tablets
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/10231
DOI: http://dx.doi.org/10.1016/j.jfoodeng.2015.09.024
Colecciones
Articulos(CIDCA)
Articulos de CENTRO DE INV EN CRIOTECNOLOGIA DE ALIMENTOS (I)
Citación
Lopez Cordoba, Alex Fernando; Gallo, Loreana Carolina; Bucala, Veronica; Martino, Miriam Nora; Navarro, Alba Sofia del Rosario; Co-crystallization of zinc sulfate with sucrose: A promissory strategy to render zinc solid dosage forms more palatable; Elsevier; Journal Of Food Engineering; 170; 2-2016; 100–107
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