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dc.contributor.author
Woo, Seng Ryong
dc.contributor.author
Fuertes, Mercedes Beatriz
dc.contributor.author
Corrales, Leticia
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Spranger, Stefani
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Furdyna, Michael J.
dc.contributor.author
Leung, Michael Y. K.
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Duggan, Ryan
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Wang, Ying
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Barber, Glen N.
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Fitzgerald, Katherine A.
dc.contributor.author
Alegre, Maria luisa
dc.contributor.author
Gajewski, Thomas F.
dc.date.available
2016-07-26T15:32:39Z
dc.date.issued
2014-11-20
dc.identifier.citation
Woo, Seng Ryong ; Fuertes, Mercedes Beatriz; Corrales, Leticia ; Spranger, Stefani ; Furdyna, Michael J. ; et al.; STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors; Cell Press; Immunity; 41; 5; 20-11-2014; 830-842
dc.identifier.issn
1074-7613
dc.identifier.uri
http://hdl.handle.net/11336/6683
dc.description.abstract
Spontaneous T cell responses against tumors occur frequently and have prognostic value in patients. The mechanism of innate immune sensing of immunogenic tumors leading to adaptive T cell responses remains undefined, although type I interferons (IFNs) are implicated in this process. We found that spontaneous CD8+ T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway. In vitro, IFN-β production and dendritic cell activation were triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3). In the tumor microenvironment in vivo, tumor cell DNA was detected within host antigen-presenting cells, which correlated with STING pathway activation and IFN-β production. Our results demonstrate that a major mechanism for innate immune sensing of cancer occurs via the host STING pathway, with major implications for cancer immunotherapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Sting
dc.subject
Dna
dc.subject
Tumor
dc.subject
Immunity
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:08:31Z
dc.identifier.eissn
1097-4180
dc.journal.volume
41
dc.journal.number
5
dc.journal.pagination
830-842
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Woo, Seng Ryong . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Fuertes, Mercedes Beatriz. University Of Chicago; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Corrales, Leticia . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Spranger, Stefani . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Furdyna, Michael J. . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Leung, Michael Y. K.. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Duggan, Ryan . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Wang, Ying . University Of Chicago; Estados Unidos
dc.description.fil
Fil: Barber, Glen N. . University Of Miami; Estados Unidos
dc.description.fil
Fil: Fitzgerald, Katherine A.. University Of Massachussets; Estados Unidos
dc.description.fil
Fil: Alegre, Maria luisa. University Of Chicago; Estados Unidos
dc.description.fil
Fil: Gajewski, Thomas F. . University Of Chicago; Estados Unidos
dc.journal.title
Immunity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.immuni.2014.10.017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384884/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/PMC4384884
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.immuni.2014.10.017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/purl/http://www.sciencedirect.com/science/article/pii/S1074761314003938
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