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dc.contributor.author Scotti, Leopoldina
dc.contributor.author Parborell, Maria Fernanda Agustina
dc.contributor.author Irusta, Griselda
dc.contributor.author de Zuñiga, Ignacio
dc.contributor.author Bisioli, Claudio
dc.contributor.author Pettorossi, Hernan
dc.contributor.author Tesone, Marta
dc.contributor.author Abramovich, Dalhia Nurit
dc.date.available 2016-06-30T18:39:52Z
dc.date.issued 2014-07-23
dc.identifier.citation Scotti, Leopoldina; Parborell, Maria Fernanda Agustina; Irusta, Griselda; de Zuñiga, Ignacio; Bisioli, Claudio; et al.; Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients; Wiley; Molecular Reproduction and Development; 81; 8; 23-7-2014; 748-756
dc.identifier.issn 1040-452X
dc.identifier.uri http://hdl.handle.net/11336/6278
dc.description.abstract Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age, and is characterized by abnormalities in ovarian angiogenesis, among other features. Consistent with this association, follicular fluid (FF) concentration and ovarian expression of vascular endothelial growth factor (VEGF) are increased in PCOS patients. In this study, we examined the protein levels of platelet-derived growth factor (PDGF) BB and DD (PDGFBB and PDGFDD), angiopoietin 1 and 2 (ANGPT1 and ANGPT2), and their soluble receptor sTIE2 in FF from PCOS and control patients undergoing assisted reproductive techniques. We also analyzed the effect of FF from PCOS and control patients on tight and adherens junction protein expression[0] in an endothelial cell line. PDGFBB and PDGFDD were significantly whereas ANGPT1 concentration was significantly higher in FF from PCOS patients than from control patients. No changes were found in the concentration of ANGPT2 or sTIE2. Expression of claudin-5 was significantly increased in endothelial cells incubated for 24 h in the presence of FF from PCOS versus from control patients, while vascular-endothelial cadherin, β-catenin, and zonula occludens 1 expression were unchanged. The changes observed in the levels of PDGF isoforms and ANGPT1 may prevent VEGF-induced vascular permeability in the PCOS ovary by regulating endothelial-cell-junction protein levels. Restoring the levels of angiogenic factors may provide new insights into PCOS treatment and the prevention of ovarian hyperstimulation syndrome in affected women.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject PLATELET-DERIVED GROWTH FACTORS
dc.subject PCOS
dc.subject FOLLICULAR FLUID
dc.subject ANGIOPOIETIN1
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Obstetricia y Ginecología
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-06-15T19:11:53Z
dc.identifier.eissn 1098-2795
dc.journal.volume 81
dc.journal.number 8
dc.journal.pagination 748-756
dc.journal.pais Estados Unidos
dc.journal.ciudad Nueva York
dc.description.fil Fil: Scotti, Leopoldina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: de Zuñiga, Ignacio. Centro Médico PREGNA Medicina Reproductiva; Argentina
dc.description.fil Fil: Bisioli, Claudio. Centro Médico PREGNA Medicina Reproductiva, ; Argentina
dc.description.fil Fil: Pettorossi, Hernan. Centro Médico PREGNA Medicina Reproductiva; Argentina
dc.description.fil Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.journal.title Molecular Reproduction and Development
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/ark/10.1002/mrd.22343
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://doi.org/10.1002/mrd.22343
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrd.22343/full


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)