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dc.contributor.author Islas, María Soledad
dc.contributor.author Luengo, Alicia
dc.contributor.author Franca, Carlos Alberto
dc.contributor.author Merino, Mercedes Griera
dc.contributor.author Calleros, Laura
dc.contributor.author Rodriguez Puyol, Manuel
dc.contributor.author Lezama, Luis
dc.contributor.author Ferrer, Evelina Gloria
dc.contributor.author Williams, Patricia Ana María
dc.date.available 2018-06-13T18:37:05Z
dc.date.issued 2016-10
dc.identifier.citation Islas, María Soledad; Luengo, Alicia; Franca, Carlos Alberto; Merino, Mercedes Griera; Calleros, Laura; et al.; Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes; Springer; Journal of Biological Inorganic Chemistry; 21; 7; 10-2016; 851-863
dc.identifier.issn 0949-8257
dc.identifier.uri http://hdl.handle.net/11336/48572
dc.description.abstract The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical calculations made in the light of the density functional theory (DFT). This compound was designed to induce structural modifications on the ligand. No antioxidant effects were displayed by both compounds, though CuIrb behaved as a weak 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenger (IC50 = 425 μM). The measurements of the contractile capacity on human mesangial cell lines showed that CuIrb improved the antihypertensive effects of the parent medication. In vitro cell growth inhibition against prostate cancer cell lines (LNCaP and DU 145) was measured for CuIrb, irbesartan and copper(II). These cell lines have been selected since the angiotensin II type 1 (AT1) receptor (that was blocked by the angiotensin receptor blockers, ARB) has been identified in them. The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand. Flow cytometry determinations were used to determine late apoptotic mechanisms of cell death.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject IRBESARTAN
dc.subject ANTIOXIDANT
dc.subject ANTIHYPERTENSIVE
dc.subject CYTOTOXICITY
dc.subject.classification Otras Ciencias Químicas
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-12T13:32:49Z
dc.identifier.eissn 1432-1327
dc.journal.volume 21
dc.journal.number 7
dc.journal.pagination 851-863
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil Fil: Luengo, Alicia. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil Fil: Merino, Mercedes Griera. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil Fil: Calleros, Laura. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil Fil: Rodriguez Puyol, Manuel. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; España
dc.description.fil Fil: Lezama, Luis. Universidad del País Vasco; España
dc.description.fil Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.description.fil Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentina
dc.journal.title Journal of Biological Inorganic Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00775-016-1384-5
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00775-016-1384-5
dc.conicet.fuente unificacion


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)