Artículo
Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins
Fecha de publicación:
12/2009
Editorial:
Sociedad Chilena de Química
Revista:
Journal of the Chilean Chemical Society
ISSN:
0717-9324
e-ISSN:
0717-9707
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of "tola", Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS + autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3',4',5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3',4',5,7-tetrahydroxy-3,6-dimethoxyfavone; 3',4',5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4',5,7-trihydroxy-3',3,6,8-tetramethoxyfavone and 4',5-dihydroxy-3',3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos(INQUINOA)
Articulos de INST.DE QUIMICA DEL NOROESTE
Articulos de INST.DE QUIMICA DEL NOROESTE
Citación
Zampini, Iris Catiana; Isla, Maria Ines; Schmeda Hirschmann, Guillermo; Antimicrobial and antioxidant compound from the infusion and methanolic extract of Baccharis incarum (Wedd.) Perkins; Sociedad Chilena de Química; Journal of the Chilean Chemical Society; 54; 4; 12-2009; 289-293
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