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dc.contributor.author
Calvo, Daniel Juan
dc.contributor.author
Beltrán González, Andrea Natalia
dc.date.available
2018-05-04T18:21:48Z
dc.date.issued
2016-07
dc.identifier.citation
Calvo, Daniel Juan; Beltrán González, Andrea Natalia; Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 90; 3; 7-2016; 326-333
dc.identifier.issn
1521-0111
dc.identifier.uri
http://hdl.handle.net/11336/44186
dc.description.abstract
Oxidizing and reducing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fast inhibitory neurotransmission mediated by γ-aminobutyric acid (GABA) receptors in the nervous system. A number of in vitro studies have shown that diverse redox compounds, including redox metabolites and reactive oxygen and nitrogen species, modulate phasic and tonic responses mediated by neuronal GABAA receptors through both pre- and postsynaptic mechanisms. We review experimental data showing that many redox agents, which are normally present in neurons and glia or are endogenously generated in these cells under physiological states or during oxidative stress (e.g: hydrogen peroxide, superoxide and hydroxyl radicals, nitric oxide, ascorbic acid, glutathione), induce potentiating or inhibiting actions on different native and recombinant GABAA receptor subtypes. Based on these results, it is thought that redox signaling might represent a homeostatic mechanism that regulates the function of synaptic and extrasynaptic GABAA receptors in physiological and pathological conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Pharmacology and Experimental Therapeutics
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gabaa Receptors
dc.subject
Redox Modulation
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dynamic Regulation of the GABAA Receptor Function by Redox Mechanisms
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-03T21:05:12Z
dc.journal.volume
90
dc.journal.number
3
dc.journal.pagination
326-333
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Baltimore
dc.description.fil
Fil: Calvo, Daniel Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
dc.description.fil
Fil: Beltrán González, Andrea Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
dc.journal.title
Molecular Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://molpharm.aspetjournals.org/content/early/recent#content-block
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1124/mol.116.105205
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