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dc.contributor.author Brunt, Elizabeth M.
dc.contributor.author Wong, Vincent W.
dc.contributor.author Nobili, Valerio
dc.contributor.author Day, Christopher P.
dc.contributor.author Sookoian, Silvia Cristina
dc.contributor.author Maher,Jackelyn J.
dc.contributor.author Bugianesi, Elizabetta
dc.contributor.author Sirlin, Claude B.
dc.contributor.author Neuschwander Tetri, Brent A.
dc.contributor.author Rinella, Mary E.
dc.date.available 2018-04-16T15:55:45Z
dc.date.issued 2015-12
dc.identifier.citation Brunt, Elizabeth M.; Wong, Vincent W.; Nobili, Valerio; Day, Christopher P.; Sookoian, Silvia Cristina; et al.; Nonalcoholic fatty liver disease; Macmillan Publishers; Nature Reviews Disease Primers; 1; 15080; 12-2015; 1-22
dc.identifier.issn 2056-676X
dc.identifier.uri http://hdl.handle.net/11336/42122
dc.description.abstract Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are additional findings of portal and lobular inflammation and hepatocyte injury (which characterize nonalcoholic steatohepatitis (NASH)). A subset of patients will develop progressive fibrosis, which can progress to cirrhosis. Hepatocellular carcinoma and cardiovascular complications are life-threatening co-morbidities of both NAFL and NASH. NAFLD is closely associated with insulin resistance; obesity and metabolic syndrome are common underlying factors. As a consequence, the prevalence of NAFLD is estimated to be 10–40% in adults worldwide, and it is the most common liver disease in children and adolescents in developed countries. Mechanistic insights into fat accumulation, subsequent hepatocyte injury, the role of the immune system and fibrosis as well as the role of the gut microbiota are unfolding. Furthermore, genetic and epigenetic factors might explain the considerable interindividual variation in disease phenotype, severity and progression. To date, no effective medical interventions exist that completely reverse the disease other than lifestyle changes, dietary alterations and, possibly, bariatric surgery. However, several strategies that target pathophysiological processes such as an oversupply of fatty acids to the liver, cell injury and inflammation are currently under investigation. Diagnosis of NAFLD can be established by imaging, but detection of the lesions of NASH still depend on the gold-standard but invasive liver biopsy. Several non-invasive strategies are being evaluated to replace or complement biopsies, especially for follow-up monitoring.
dc.format application/pdf
dc.language.iso eng
dc.publisher Macmillan Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject FATTY LIVER
dc.subject NASH
dc.subject PATHOGENESIS
dc.subject REVIEW
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Nonalcoholic fatty liver disease
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-04-13T14:32:46Z
dc.journal.volume 1
dc.journal.number 15080
dc.journal.pagination 1-22
dc.journal.pais Reino Unido
dc.journal.ciudad London
dc.description.fil Fil: Brunt, Elizabeth M.. University of Washington; Estados Unidos
dc.description.fil Fil: Wong, Vincent W.. The Chinese University of Hong Kong. Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease; Hong Kong
dc.description.fil Fil: Nobili, Valerio. Bambino Gesu Children Hospital. Hepatometabolic Unit; Italia
dc.description.fil Fil: Day, Christopher P.. University of Newcastle; Reino Unido
dc.description.fil Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil Fil: Maher,Jackelyn J.. University of California; Estados Unidos
dc.description.fil Fil: Bugianesi, Elizabetta. Università di Torino; Italia
dc.description.fil Fil: Sirlin, Claude B.. University of California at San Diego., Department of Radiology. Liver Imaging Group; Estados Unidos
dc.description.fil Fil: Neuschwander Tetri, Brent A.. University School of Medicine, Saint Louis. Division of Gastroenterology and Hepatology; Estados Unidos
dc.description.fil Fil: Rinella, Mary E.. Northwestern University. Department of Medicine, Feinberg School of Medicine; Estados Unidos
dc.journal.title Nature Reviews Disease Primers
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nrdp201580
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nrdp.2015.80
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)