Mostrar el registro sencillo del ítem
dc.contributor.author
Brunt, Elizabeth M.
dc.contributor.author
Wong, Vincent W.
dc.contributor.author
Nobili, Valerio
dc.contributor.author
Day, Christopher P.
dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Maher,Jackelyn J.
dc.contributor.author
Bugianesi, Elizabetta
dc.contributor.author
Sirlin, Claude B.
dc.contributor.author
Neuschwander Tetri, Brent A.
dc.contributor.author
Rinella, Mary E.
dc.date.available
2018-04-16T15:55:45Z
dc.date.issued
2015-12
dc.identifier.citation
Brunt, Elizabeth M.; Wong, Vincent W.; Nobili, Valerio; Day, Christopher P.; Sookoian, Silvia Cristina; et al.; Nonalcoholic fatty liver disease; Macmillan Publishers; Nature Reviews Disease Primers; 1; 15080; 12-2015; 1-22
dc.identifier.issn
2056-676X
dc.identifier.uri
http://hdl.handle.net/11336/42122
dc.description.abstract
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are additional findings of portal and lobular inflammation and hepatocyte injury (which characterize nonalcoholic steatohepatitis (NASH)). A subset of patients will develop progressive fibrosis, which can progress to cirrhosis. Hepatocellular carcinoma and cardiovascular complications are life-threatening co-morbidities of both NAFL and NASH. NAFLD is closely associated with insulin resistance; obesity and metabolic syndrome are common underlying factors. As a consequence, the prevalence of NAFLD is estimated to be 10–40% in adults worldwide, and it is the most common liver disease in children and adolescents in developed countries. Mechanistic insights into fat accumulation, subsequent hepatocyte injury, the role of the immune system and fibrosis as well as the role of the gut microbiota are unfolding. Furthermore, genetic and epigenetic factors might explain the considerable interindividual variation in disease phenotype, severity and progression. To date, no effective medical interventions exist that completely reverse the disease other than lifestyle changes, dietary alterations and, possibly, bariatric surgery. However, several strategies that target pathophysiological processes such as an oversupply of fatty acids to the liver, cell injury and inflammation are currently under investigation. Diagnosis of NAFLD can be established by imaging, but detection of the lesions of NASH still depend on the gold-standard but invasive liver biopsy. Several non-invasive strategies are being evaluated to replace or complement biopsies, especially for follow-up monitoring.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Macmillan Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fatty Liver
dc.subject
Nash
dc.subject
Pathogenesis
dc.subject
Review
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nonalcoholic fatty liver disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-13T14:32:46Z
dc.journal.volume
1
dc.journal.number
15080
dc.journal.pagination
1-22
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Brunt, Elizabeth M.. University of Washington; Estados Unidos
dc.description.fil
Fil: Wong, Vincent W.. The Chinese University of Hong Kong. Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease; Hong Kong
dc.description.fil
Fil: Nobili, Valerio. Bambino Gesu Children Hospital. Hepatometabolic Unit; Italia
dc.description.fil
Fil: Day, Christopher P.. University of Newcastle; Reino Unido
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Maher,Jackelyn J.. University of California; Estados Unidos
dc.description.fil
Fil: Bugianesi, Elizabetta. Università di Torino; Italia
dc.description.fil
Fil: Sirlin, Claude B.. University of California at San Diego., Department of Radiology. Liver Imaging Group; Estados Unidos
dc.description.fil
Fil: Neuschwander Tetri, Brent A.. University School of Medicine, Saint Louis. Division of Gastroenterology and Hepatology; Estados Unidos
dc.description.fil
Fil: Rinella, Mary E.. Northwestern University. Department of Medicine, Feinberg School of Medicine; Estados Unidos
dc.journal.title
Nature Reviews Disease Primers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nrdp201580
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nrdp.2015.80
Archivos asociados