Artículo
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
Cayrol, Maria Florencia
; Díaz Flaqué, María Celeste
; Tharu, Fernando; Yang, Shao Ning; Sterle, Helena Andrea
; Bolontrade, Marcela Fabiana
; Amorós, Mariana Andrea
; Isse, Blanca Alicia de Los Angeles G.; Farias, Ricardo Norberto
; Ahn, Haelee; Tian, Ye F.; Tabbò, Fabrizio; Singh, Ajnesh; Inghirami, Giorgio; Cerchietti, Leandro
; Cremaschi, Graciela Alicia
Fecha de publicación:
01/2015
Editorial:
American Society of Hematology
Revista:
Blood
ISSN:
0006-4971
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin αvβ3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin αvβ3 ligands, activated growth-related signaling pathways in T-cell lymphomas (TCLs). Specifically, TH-activated αvβ3 integrin signaling promoted TCL proliferation and angiogenesis, in part, via the upregulation of vascular endothelial growth factor (VEGF). Consequently, genetic or pharmacologic inhibition of integrin αvβ3 decreased VEGF production and induced TCL cell death in vitro and in human xenograft models. In sum, we show that integrin αvβ3 transduces prosurvival signals into TCL nuclei, suggesting a novel mechanism for the endocrine modulation of TCL pathophysiology. Targeting this mechanism could constitute an effective and potentially low-toxicity chemotherapy-free treatment of TCL patients.
Palabras clave:
Lymphoid Tumor Cells
,
Integrin Αvβ3
,
Tcl Proliferation
,
Endocrine Modulation
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(BIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Cayrol, Maria Florencia; Díaz Flaqué, María Celeste; Tharu, Fernando; Yang, Shao Ning; Sterle, Helena Andrea; et al.; Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells; American Society of Hematology; Blood; 125; 5; 1-2015; 841-851
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