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dc.contributor.author
Koo, Sue Jie
dc.contributor.author
Spratt, Heidi M.
dc.contributor.author
Soman, Kizhake V.
dc.contributor.author
Stafford, Susan
dc.contributor.author
Gupta, Shivali
dc.contributor.author
Petersen, John R.
dc.contributor.author
Zago, María Paola
dc.contributor.author
Kuyumcu Martinez, Muge N.
dc.contributor.author
Brasier, Allan R.
dc.contributor.author
Wiktorowicz, John E.
dc.contributor.author
Garg, Nisha Jain
dc.date.available
2018-02-27T18:32:09Z
dc.date.issued
2016
dc.identifier.citation
Koo, Sue Jie; Spratt, Heidi M.; Soman, Kizhake V.; Stafford, Susan; Gupta, Shivali; et al.; S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure; Hindawi Publishing Corporation; International Journal of Proteomics; 2016; 2016; 1-19; 1384523
dc.identifier.issn
2090-2174
dc.identifier.uri
http://hdl.handle.net/11336/37293
dc.description.abstract
Nitric oxide (NO) protects the heart against ischemic injury; however, NO- and superoxide-dependent S-nitrosylation (S-NO) of cysteines can affect function of target proteins and play a role in disease outcome. We employed 2D-GE with thiol-labeling FL-maleimide dye and MALDI-TOF MS/MS to capture the quantitative changes in abundance and S-NO proteome of HF patients (versus healthy controls, n = 30/group). We identified 93 differentially abundant (59-increased/34-decreased) and 111 S-NO-modified (63-increased/48-decreased) protein spots, respectively, in HF subjects (versus controls, fold-change | ≥1.5|, p ≤ 0.05). Ingenuity pathway analysis of proteome datasets suggested that the pathways involved in phagocytes´ migration, free radical production, and cell death were activated and fatty acid metabolism was decreased in HF subjects. Multivariate adaptive regression splines modeling of datasets identified a panel of proteins that will provide >90% prediction success in classifying HF subjects. Proteomic profiling identified ATP-synthase, thrombospondin-1 (THBS1), and vinculin (VCL) as top differentially abundant and S-NO-modified proteins, and these proteins were verified by Western blotting and ELISA in different set of HF subjects. We conclude that differential abundance and S-NO modification of proteins serve as a mechanism in regulating cell viability and free radical production, and THBS1 and VCL evaluation will potentially be useful in the prediction of heart failure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
S-Nitrosylation
dc.subject
Proteomic Profiling
dc.subject
Heart Failure
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-01T18:04:13Z
dc.journal.volume
2016
dc.journal.pagination
1-19; 1384523
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Koo, Sue Jie. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Spratt, Heidi M.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Soman, Kizhake V.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Stafford, Susan. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Gupta, Shivali. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Petersen, John R.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Kuyumcu Martinez, Muge N.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Brasier, Allan R.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Wiktorowicz, John E.. University of Texas Medical Branch; Estados Unidos
dc.description.fil
Fil: Garg, Nisha Jain. University of Texas Medical Branch; Estados Unidos
dc.journal.title
International Journal of Proteomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2016/1384523
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijpro/2016/1384523/
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