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dc.contributor.author Pazos Maidana, María Camila
dc.contributor.author Sequeira, Gonzalo Ricardo
dc.contributor.author Bocchicchio, Sebastian
dc.contributor.author May, Maria
dc.contributor.author Abramovich, Dalhia Nurit
dc.contributor.author Parborell, Maria Fernanda Agustina
dc.contributor.author Tesone, Marta
dc.contributor.author Irusta, Griselda
dc.date.available 2018-02-12T15:50:34Z
dc.date.issued 2017-12-20
dc.identifier.citation Pazos Maidana, María Camila; Sequeira, Gonzalo Ricardo; Bocchicchio, Sebastian; May, Maria; Abramovich, Dalhia Nurit; et al.; PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Physiology; 20-12-2017
dc.identifier.issn 0021-9541
dc.identifier.uri http://hdl.handle.net/11336/36419
dc.description.abstract Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed. These facts show the clear need to find new therapeutic strategies for this illness. Thus, the aim of the present study was to investigate the effect of a gamma-secretase inhibitor (DAPT) in combination with the Platelet-derived growth factor B (PDGFB) on an ovarian cancer xenograft model. To achieve this goal, we analyzed the effect of the administration of DAPT alone and the co-administration of DAPT and recombinant PDGFB on parameters associated with tumour growth and angiogenesis in an orthotopic experimental model of ovarian cancer. We observed that the dose of DAPT used was ineffective to reduce ovarian tumour growth, but showed anticancer activity when co-administered with recombinant PDGFB. The administration of PDGFB alone normalized tumour vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. Our findings suggest that PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. We propose that this therapeutic strategy could be a new tool for ovarian cancer treatment and deserves further studies.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley-liss, Div John Wiley & Sons Inc
dc.rights info:eu-repo/semantics/embargoedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject OVARIAN CANCER
dc.subject NOTCH SYSTEM
dc.subject PDGFB
dc.subject NORMALIZATION
dc.subject ANGIOGENESIS
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Oncología
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-02-05T13:42:38Z
dc.journal.pais Estados Unidos
dc.journal.ciudad New York
dc.conicet.avisoEditorial This is the pre-peer reviewed version of the following article:Pazos, M. C., et al. "PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma‐secretase inhibitor." Journal of cellular physiology (2017), which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jcp.26404/abstract This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
dc.description.fil Fil: Pazos Maidana, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Bocchicchio, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title Journal of Cellular Physiology
dc.rights.embargoDate 2019-01-01
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/jcp.26404
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jcp.26404
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/29266203
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info:eu-repo/semantics/embargoedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)