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dc.contributor.author Bustuoabad, Oscar David
dc.contributor.author di Gianni, Pedro D.
dc.contributor.author Franco, Marcela
dc.contributor.author Kordon, Edith Claudia
dc.contributor.author Vanzulli, Silvia I.
dc.contributor.author Meiss, Roberto P.
dc.contributor.author Grion, Lorena C.
dc.contributor.author Diaz, Graciela Susana
dc.contributor.author Nosetto, Sergio H.
dc.contributor.author Hockl, Pablo Francisco
dc.contributor.author Lombardi, María Gabriela
dc.contributor.author Pasqualini, Christiane Dosne
dc.contributor.author Ruggiero, Raul Alejandro
dc.date.available 2018-02-11T23:49:22Z
dc.date.issued 2002-01
dc.identifier.citation Bustuoabad, Oscar David; di Gianni, Pedro D.; Franco, Marcela; Kordon, Edith Claudia; Vanzulli, Silvia I.; et al.; Embryonal mass and hormone-associated effects of pregnancy inducing a differential growth of four murine tumors; Cognizant Communication Corp; Oncology Research; 1-2002; 147-160
dc.identifier.issn 0965-0407
dc.identifier.uri http://hdl.handle.net/11336/36415
dc.description.abstract A differential effect of pregnancy on the growth of subcutaneous implants of four murine tumors has been observed. Two tumors lacking receptors for progesterone and estrogen [methylcholanthrene-induced fibrosarcoma (MC-C) and spontaneous lymphoid leukemia (LB)] exhibited slow kinetics throughout the course of pregnancy, although inhibition was stronger beyond day 10. On the other hand, one of two tumors bearing receptors for progesterone and estrogen [medroxyprogesterone (MPA)-induced mammary adenocarcinoma (C7HI)] exhibited three phases: up to days 8-10 of gestation the tumor grew faster than in virgins, between days 8-10 and 15 it reached a plateau, and beyond day 15 a sharp reduction in tumor mass was observed. The other tumor [mouse mammary tumor virus (MMTV)-induced mammary carcinoma(T2280)] behaved as a typical pregnancy-dependent tumor (i.e., it grew in pregnant but not in virgin mice, regressed soon after delivery, and reassumed its growth at the middle of a second round of pregnancy). Neither MPA nor estrogen affected MC-C and LB tumor growth. On the other hand, MPA-treated mice enhanced C7HI tumor and reciprocally C7HI tumor-bearing mice treated with estrogen strongly inhibited tumor growth. As for T2280, neither MPA nor estrogen alone could promote tumor growth and, in consequence, no tumor developed. However, when MPA plus estrogen was administered in a schedule simulating the successive appearance of these hormones in pregnancy, T2280 grew even faster than in pregnant mice. When the four tumors were implanted in mice bearing grafts of embryonal tissues (teratomas), all of them were inhibited. This antitumor effect was similar to that observed in pregnancy when tumors unresponsive to progesterone and estrogen were tested. On the other hand, with tumors bearing progesterone and estrogen receptors, differences in tumor growth were detected in pregnant and teratoma-bearing mice. This suggested the existence during pregnancy of two factors potentially acting on tumor growth. First, a progesterone and estrogen-mediated hormonal component, which would exert either inhibitory or stimulatory effects only evidenced with tumors bearing hormonal receptors. Secondly, an antitumor effect proportional to the growing embryonal mass, inhibiting all tumors independently of their origin or hormone responsiveness. This antitumor effect could be attributed to a beat-resistant serum factor (1,000-1,200 Da molecular weight) presumably associated with the pathway of the arachidonic acid metabolism. The interplay between the hormonal component and the serum factor associated with embryonal mass could account for some of the largely heterogeneous and otherwise unexplained effects of pregnancy on tumor growth reported in the literature and illustrated by the four tumors studied here.
dc.format application/pdf
dc.language.iso eng
dc.publisher Cognizant Communication Corp
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject TNFa
dc.subject LIF
dc.subject ERK
dc.subject MAMMARY INVOLUTION
dc.subject MURINE TUMORS
dc.subject PREGNANCY
dc.subject HORMONE REGULATION
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Embryonal mass and hormone-associated effects of pregnancy inducing a differential growth of four murine tumors
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-01-12T19:28:28Z
dc.journal.pagination 147-160
dc.journal.pais Estados Unidos
dc.description.fil Fil: Bustuoabad, Oscar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil Fil: di Gianni, Pedro D.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Franco, Marcela. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Kordon, Edith Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Vanzulli, Silvia I.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Meiss, Roberto P.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Grion, Lorena C.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Diaz, Graciela Susana. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Nosetto, Sergio H.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Hockl, Pablo Francisco. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Lombardi, María Gabriela. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Pasqualini, Christiane Dosne. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.journal.title Oncology Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.cognizantcommunication.com/cccSiteFiles/Oncology/oradd13abs3.html
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/12549624
dc.conicet.fuente unificacion


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)