Artículo
Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity
Avila, Cesar Luis
; Torres Bugeau, Clarisa Maria
; Barbosa, Leandro R. S.; Morandé Sales, Elisa; Ouidja, Mohand O.; Socías, Sergio B.; Celej, Maria Soledad
; Raisman Vozari, Rita; Garcia Orozco Ep Papy, Dulce Maria; Itri, Rosangela; Chehin, Rosana Nieves
Fecha de publicación:
03/2014
Editorial:
American Society for Biochemistry and Molecular Biology
Revista:
Journal of Biological Chemistry (online)
ISSN:
0021-9258
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background:Although glycosaminoglycan-induced GAPDH prefibrillar species accelerates -synuclein aggregation, itsrole in toxicity remains unclear.Results:The toxic effect exerted by -synuclein oligomers on cell culture was abolished by GAPDH protofibril, which wasidentified and structurally characterized.Conclusion:GAPDH protofibrils can efficiently sequester -synuclein toxic oligomers.Significance:GAPDH protofibrils may play an important role in neuronal proteostasis and could open a novel therapeuticstrategy for synucleinopathies.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Avila, Cesar Luis; Torres Bugeau, Clarisa Maria; Barbosa, Leandro R. S.; Morandé Sales, Elisa; Ouidja, Mohand O.; et al.; Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 3-2014; 13838-13850
Compartir
Altmétricas