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dc.contributor.author Morgenstern, Nicolás Andrés
dc.contributor.author Lombardi, María Gabriela
dc.contributor.author Schinder, Alejandro Fabián
dc.date.available 2017-12-05T19:41:25Z
dc.date.issued 2008-06
dc.identifier.citation Morgenstern, Nicolás Andrés; Lombardi, María Gabriela; Schinder, Alejandro Fabián; Newborn granule cells in the ageing dentate gyrus; Wiley Blackwell Publishing, Inc; The Journal Of Physiology; 586; 16; 6-2008; 3751-3757
dc.identifier.issn 0022-3751
dc.identifier.uri http://hdl.handle.net/11336/29778
dc.description.abstract The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in the ageing hippocampus, the specific characteristics of dentate granule cells born in such a continuously changing environment have received little attention. We have used retroviral labelling of neural progenitor cells of the adult mouse dentate gyrus to study morphological properties of neurons born at different ages. Dendritic spine density was measured to estimate glutamatergic afferent connectivity. Fully mature neurons born at the age of 2 months display approximately 2.3 spines microm(-1) and maintain their overall morphology and spine density in 1-year-old mice. Surprisingly, granule cells born in 10-month-old mice, at which time the rate of neurogenesis has decreased by approximately 40-fold, reach a density of dendritic spines similar to that of neurons born in young adulthood. Therefore, in spite of the sharp decline in cell proliferation, differentiation and overall neuronal number, the ageing hippocampus presents a suitable environment for new surviving neurons to reach a high level of complexity, comparable to that of all other dentate granule cells
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley Blackwell Publishing, Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Granule Cells
dc.subject Animals, Newborn
dc.subject Cell Differentiation
dc.subject Cell Proliferation
dc.subject Ageing
dc.subject Dentate Gyrus
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Newborn granule cells in the ageing dentate gyrus
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-11-24T14:39:55Z
dc.identifier.eissn 1469-7793
dc.journal.volume 586
dc.journal.number 16
dc.journal.pagination 3751-3757
dc.journal.pais Reino Unido
dc.journal.ciudad Oxford
dc.description.fil Fil: Morgenstern, Nicolás Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title The Journal Of Physiology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2008.154807/abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1113/jphysiol.2008.154807


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)