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dc.contributor.author
Romarowski, Ana
dc.contributor.author
Sánchez Cárdenas, Claudia
dc.contributor.author
Ramírez Gómez, Héctor V.
dc.contributor.author
Puga Molina, Lis del Carmen
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Treviño, Claudia L.
dc.contributor.author
Hernández Cruz, Arturo
dc.contributor.author
Darszon, Alberto I.
dc.contributor.author
Buffone, Mariano Gabriel
dc.date.available
2017-08-25T20:32:01Z
dc.date.issued
2016-03-01
dc.identifier.citation
Romarowski, Ana; Sánchez Cárdenas, Claudia; Ramírez Gómez, Héctor V.; Puga Molina, Lis del Carmen; Treviño, Claudia L.; et al.; A specific transitory increase in intracellular calcium induced by progesterone promotes acrosomal exocytosis in mouse sperm; Society for the Study of Reproduction; Biology of Reproduction; 94; 3; 1-3-2016; 1-12
dc.identifier.issn
0006-3363
dc.identifier.uri
http://hdl.handle.net/11336/23038
dc.description.abstract
During capacitation, sperm acquire the ability to undergo the acrosome reaction (AR), an essential step in fertilization. Progesterone produced by cumulus cells has been associated with various physiological processes in sperm, including stimulation of AR. An increase in intracellular Ca2+ ([Ca2+]i) is necessary for AR to occur. In this study, we investigated the spatio- temporal correlation between the changes in [Ca2+]i and AR in single mouse spermatozoa in response to Progesterone. We found that Progesterone stimulates an [Ca2+]i increase in five different patterns: gradual increase, oscillatory, late transitory, immediate transitory and sustained. We also observed that the [Ca2+]i increase promoted by Progesterone starts at either the flagellum or the head. We validated the use of FM4-64 as an indicator for the occurrence of the AR by simultaneously detecting its fluorescence increase and the loss of EGFP in transgenic EGFPAcr sperm. For the first time, we have simultaneously visualized the rise in [Ca2+]i and the process of exocytosis in response to Progesterone and found that only a specific transitory increase in [Ca2+]i originated in the sperm head promotes the initiation of AR.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for the Study of Reproduction
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sperm
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Acrosomal Exocytosis
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Calcium
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Progesterone
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A specific transitory increase in intracellular calcium induced by progesterone promotes acrosomal exocytosis in mouse sperm
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-09T16:57:00Z
dc.identifier.eissn
1529-7268
dc.journal.volume
94
dc.journal.number
3
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Champaing
dc.description.fil
Fil: Romarowski, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Sánchez Cárdenas, Claudia. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
dc.description.fil
Fil: Ramírez Gómez, Héctor V.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
dc.description.fil
Fil: Puga Molina, Lis del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Treviño, Claudia L.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
dc.description.fil
Fil: Hernández Cruz, Arturo. Universidad Nacional Autónoma de México. Instituto de Fisiología Celular; México
dc.description.fil
Fil: Darszon, Alberto I.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
dc.description.fil
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Biology of Reproduction
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod.115.136085
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1095/biolreprod.115.136085
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829090/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/26819478
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