Artículo
Angiogenesis in pituitary adenomas: human studies and new mutant mouse models
Cristina, Silvia Carolina
; Luque, Guillermina Maria
; Demarchi, Gianina
; López Vicchi, María Felicitas
; Zubeldia Brenner, Lautaro
; Pérez Millán, María Inés
; Perrone, Sofía
; Ornstein, Ana Maria
; Lacau, Isabel Maria
; Berner, Silvia Inés; Becu, Damasia
Fecha de publicación:
18/11/2014
Editorial:
Hindawi Publishing Corporation
Revista:
International Journal of Endocrinology
ISSN:
1687-8337
e-ISSN:
1687-8345
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue. Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to noninvasive and microprolactinomas. Many growth factors and their receptors are involved in pituitary tumor development. For example, VEGF, FGF-2, FGFR1, and PTTG, which give a particular vascular phenotype, are modified in human and experimental pituitary adenomas of different histotypes. In particular, vascular endothelial growth factor, VEGF, the central mediator of angiogenesis in endocrine glands, was encountered in experimental and human pituitary tumors at different levels of expression and, in particular, was higher in dopamine agonist resistant prolactinomas. Furthermore, several anti-VEGF techniques lowered tumor burden in human and experimental pituitary adenomas. Therefore, even though the role of angiogenesis in pituitary adenomas is contentious, VEGF, making permeable pituitary endothelia, might contribute to adequate temporal vascular supply and mechanisms other than endothelial cell proliferation. The study of angiogenic factor expression in aggressive prolactinomas with resistance to dopamine agonists will yield important data in the search of therapeutical alternatives.
Palabras clave:
Pituitary
,
Adenomas
,
Angiogenesis
,
Vegf
Archivos asociados
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Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Cristina, Silvia Carolina; Luque, Guillermina Maria; Demarchi, Gianina; López Vicchi, María Felicitas; Zubeldia Brenner, Lautaro; et al.; Angiogenesis in pituitary adenomas: human studies and new mutant mouse models; Hindawi Publishing Corporation; International Journal of Endocrinology; 2014; 18-11-2014; 1-11
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