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dc.contributor.author
Colas, E.
dc.contributor.author
Muinelo Romay, L.
dc.contributor.author
Alonso Alconada, L.
dc.contributor.author
Llaurado, M.
dc.contributor.author
Monge, M,
dc.contributor.author
Barbazan, J.
dc.contributor.author
Gonzalez, M.
dc.contributor.author
Schoumacher, M.
dc.contributor.author
Pedrola, N.
dc.contributor.author
Ertekin, T.
dc.contributor.author
Devis, L.
dc.contributor.author
Ruiz, A.
dc.contributor.author
Castellvi, J.
dc.contributor.author
Doll, A.
dc.contributor.author
Gil Moreno, A,
dc.contributor.author
Vazquez, Monica Hebe
dc.contributor.author
Lapyckyj, Lara
dc.contributor.author
Lopez Lopez, R.
dc.contributor.author
Robine, S.
dc.contributor.author
Friederich, E.
dc.contributor.author
Castro, M.
dc.contributor.author
Reventos, J.
dc.contributor.author
Vignjevic, D.
dc.contributor.author
Abal, M.
dc.date.available
2017-08-18T15:22:33Z
dc.date.issued
2012-01-23
dc.identifier.citation
Colas, E.; Muinelo Romay, L.; Alonso Alconada, L.; Llaurado, M.; Monge, M,; et al.; ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas; Nature Publishing Group; Oncogene; 31; 23-1-2012; 4778-4788
dc.identifier.issn
0950-9232
dc.identifier.uri
http://hdl.handle.net/11336/22664
dc.description.abstract
Endometrial carcinoma (EC) is the most frequent among infiltrating tumors of the female genital tract, with myometrial invasion representing an increase in the rate of recurrences and a decrease in survival. We have previously described ETV5 transcription factor associated with myometrial infiltration in human ECs. In this work, we further investigated ETV5 orchestrating downstream effects to confer the tumor the invasive capabilities needed to disseminate in the early stages of EC dissemination. Molecular profiling evidenced ETV5 having a direct role on epithelial-to-mesenchymal transition (EMT). In particular, ETV5 modulated Zeb1 expression and E-Cadherin repression leading to a complete reorganization of cell-cell and cell-substrate contacts. ETV5-promoted EMT resulted in the acquisition of migratory and invasive capabilities in endometrial cell lines. Furthermore, we identified the lipoma-preferred partner protein as a regulatory partner of ETV5, acting as a sensor for extracellular signals promoting tumor invasion. All together, we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Etv5
dc.subject
Endometrial Carcinoma
dc.subject
Lpp
dc.subject
Emt
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-29T13:39:29Z
dc.identifier.eissn
1476-5594
dc.journal.volume
31
dc.journal.pagination
4778-4788
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Colas, E.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Muinelo Romay, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
dc.description.fil
Fil: Alonso Alconada, L.. Complexo Hospitalario Universitario de Santiago SERGAS; España
dc.description.fil
Fil: Llaurado, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Monge, M,. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Barbazan, J.. Complexo Hospitalario Universitario de Santiago SERGAS; España
dc.description.fil
Fil: Gonzalez, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Schoumacher, M.. Institute Curie; Francia
dc.description.fil
Fil: Pedrola, N.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Ertekin, T.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Devis, L.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Ruiz, A.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Castellvi, J.. Universidad Autónoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Doll, A.. Universidad Autónoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Gil Moreno, A,. Universidad Autonoma de Barcelona. Hospital Vall D; España. Universidad de Barcelona; España
dc.description.fil
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Lopez Lopez, R.. Complexo Hospitalario Universitario de Santiago SERGAS; España
dc.description.fil
Fil: Robine, S.. Institute Curie; Francia
dc.description.fil
Fil: Friederich, E.. Complexo Hospitalario Universitario de Santiago SERGAS; España
dc.description.fil
Fil: Castro, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Reventos, J.. Universidad de Santiago de Compostela; España. Universidad Autonoma de Barcelona. Hospital Vall D; España
dc.description.fil
Fil: Vignjevic, D.. Institute Curie; Francia
dc.description.fil
Fil: Abal, M.. Universidad Autonoma de Barcelona. Hospital Vall D; España. Complexo Hospitalario Universitario de Santiago SERGAS;; España
dc.journal.title
Oncogene
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/onc/journal/v31/n45/full/onc2011632a.html?foxtrotcallback=true
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/onc.2011.632
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