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dc.contributor.author
Cosin Roge, Jesús
dc.contributor.author
Vernia, Santiago
dc.contributor.author
Alvarez, María Soledad
dc.contributor.author
Cucarella, Carme
dc.contributor.author
Boscá, Lisardo
dc.contributor.author
Martin Sanz, Paloma
dc.contributor.author
Fernández Alvarez, Ana Julia
dc.contributor.author
Casado, Marta
dc.date.available
2017-07-04T20:32:17Z
dc.date.issued
2013-02
dc.identifier.citation
Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; et al.; Identification of a novel Pfkfb1 mRNA variant in rat fetal liver; Elsevier; Biochemical And Biophysical Research Communications; 431; 1; 2-2013; 36-40
dc.identifier.issn
0006-291X
dc.identifier.uri
http://hdl.handle.net/11336/19538
dc.description.abstract
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pfk
dc.subject
Fetal Liver
dc.subject
Splicing
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-05T13:12:44Z
dc.identifier.eissn
1090-2104
dc.journal.volume
431
dc.journal.number
1
dc.journal.pagination
36-40
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Cosin Roge, Jesús. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Vernia, Santiago. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Alvarez, María Soledad. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Cucarella, Carme. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Boscá, Lisardo. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Martin Sanz, Paloma. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Fernández Alvarez, Ana Julia. Consejo Superior de Investigaciones Cientificas; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Casado, Marta. Consejo Superior de Investigaciones Cientificas; España
dc.journal.title
Biochemical And Biophysical Research Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X12024692
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbrc.2012.12.109
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